Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice
MR Alexander, CW Moehle, JL Johnson… - The Journal of …, 2012 - Am Soc Clin Investig
Clinical complications of atherosclerosis arise primarily as a result of luminal obstruction due
to atherosclerotic plaque growth, with inadequate outward vessel remodeling and plaque …
to atherosclerotic plaque growth, with inadequate outward vessel remodeling and plaque …
Insulin-like growth factor-1 receptor deficiency in macrophages accelerates atherosclerosis and induces an unstable plaque phenotype in apolipoprotein E–deficient …
Y Higashi, S Sukhanov, SY Shai, S Danchuk, R Tang… - Circulation, 2016 - Am Heart Assoc
Background—We have previously shown that systemic infusion of insulin-like growth factor-
1 (IGF-1) exerts anti-inflammatory and antioxidant effects and reduces atherosclerotic …
1 (IGF-1) exerts anti-inflammatory and antioxidant effects and reduces atherosclerotic …
Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis
B Schieffer, T Selle, A Hilfiker, D Hilfiker-Kleiner… - Circulation, 2004 - Am Heart Assoc
Background—Vascular lipid accumulation and inflammation are hallmarks of
atherosclerosis and perpetuate atherosclerotic plaque development. Mediators of …
atherosclerosis and perpetuate atherosclerotic plaque development. Mediators of …
Lack of interleukin-1 receptor antagonist modulates plaque composition in apolipoprotein E–deficient mice
K Isoda, S Sawada, N Ishigami, T Matsuki… - … , and vascular biology, 2004 - Am Heart Assoc
Objective—Interleukin (IL)-1 plays an important role in atherosclerosis. IL-1 receptor
antagonist (IL-1Ra) is an endogenous inhibitor of IL-1. However, the role of IL-1Ra in the …
antagonist (IL-1Ra) is an endogenous inhibitor of IL-1. However, the role of IL-1Ra in the …
Atheroprotective role of interleukin-6 in diet-and/or pathogen-associated atherosclerosis using an ApoE heterozygote murine model
M Madan, B Bishayi, M Hoge, S Amar - Atherosclerosis, 2008 - Elsevier
BACKGROUND: Pathogens have been implicated in the pathogenesis of inflammatory
atherosclerosis. Given the pleiotropic role of interleukin-6 in the regulation of cytokines, lipid …
atherosclerosis. Given the pleiotropic role of interleukin-6 in the regulation of cytokines, lipid …
Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis
A Vromman, V Ruvkun, E Shvartz… - European heart …, 2019 - academic.oup.com
Abstract Aims Targeting interleukin-1 (IL-1) represents a novel therapeutic approach to
atherosclerosis. CANTOS demonstrated the benefits of IL-1β neutralization in patients post …
atherosclerosis. CANTOS demonstrated the benefits of IL-1β neutralization in patients post …
[HTML][HTML] IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype
JH von der Thüsen, KS Borensztajn, S Moimas… - The American journal of …, 2011 - Elsevier
Insulin-like growth factor-1 (IGF-1) signaling is important for the maintenance of plaque
stability in atherosclerosis due to its effects on vascular smooth muscle cell (vSMC) …
stability in atherosclerosis due to its effects on vascular smooth muscle cell (vSMC) …
Compensatory vascular remodeling during atherosclerotic lesion growth depends on matrix metalloproteinase-9 activity
SM Lessner, DE Martinson, ZS Galis - … , thrombosis, and vascular …, 2004 - Am Heart Assoc
Objective—The compensatory arterial remodeling associated with atherosclerotic plaques is
thought to rely on the activity of matrix metalloproteinases (MMP). To assess the role of MMP …
thought to rely on the activity of matrix metalloproteinases (MMP). To assess the role of MMP …
Smooth Muscle Cell–Specific Insulin-Like Growth Factor-1 Overexpression in Apoe−/− Mice Does Not Alter Atherosclerotic Plaque Burden but Increases Features of …
SY Shai, S Sukhanov, Y Higashi… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—Growth factors may play a permissive role in atherosclerosis initiation and
progression, in part via their promotion of vascular smooth muscle cell (VSMC) accumulation …
progression, in part via their promotion of vascular smooth muscle cell (VSMC) accumulation …
Matrix metalloproteinase-9 modulation by resident arterial cells is responsible for injury-induced accelerated atherosclerotic plaque development in apolipoprotein E …
ET Choi, ET Collins, LA Marine, MG Uberti… - … , and vascular biology, 2005 - Am Heart Assoc
Objective—Although matrix metalloproteinase-9 (MMP-9) has been implicated in
atherosclerotic plaque instability, the exact role it plays in the plaque development and …
atherosclerotic plaque instability, the exact role it plays in the plaque development and …