Lead nitrate induces inflammation and apoptosis in rat lungs through the activation of NF-κB and AhR signaling pathways

IM Attafi, SA Bakheet, SF Ahmad, OM Belali… - … Science and Pollution …, 2022 - Springer
Lead (Pb) is one of the most frequent hazardous air contaminants, where the lungs are
particularly vulnerable to its toxicity. However, the Pb distribution and its impact on lung …

The role of NF-κB and AhR transcription factors in lead-induced lung toxicity in human lung cancer A549 cells

IM Attafi, SA Bakheet, HM Korashy - Toxicology mechanisms and …, 2020 - Taylor & Francis
Lead (Pb) is recognized as the first heavy metal of the top six toxic air pollutants threatening
human health and the second hazardous substance. Pb exposure is associated with lung …

Acute 1-NP exposure induces inflammatory responses through activating various inflammatory signaling pathways in mouse lungs and human A549 cells

B Hu, B Tong, Y Xiang, SR Li, ZX Tan, HX Xiang… - Ecotoxicology and …, 2020 - Elsevier
Nitropyrene (1-NP), a key component of fine particulate matter (PM2. 5), is a representative
of nitrated polycyclic aromatic hydrocarbons (NPAHs). The aim of this research is to …

Preventive effect of TiO2 nanoparticles on heavy metal Pb-induced toxicity in human lung epithelial (A549) cells

M Ahamed, MJ Akhtar, HA Alhadlaq - Toxicology in Vitro, 2019 - Elsevier
Wide application of TiO 2 nanoparticles (nTiO 2) and ubiquitous lead (Pb) pollution in
natural environment enhance the chance of co-exposure of humans to Pb and nTiO 2. We …

Lead nitrate induced apoptosis in alveolar macrophages from rat lung

A Shabani, A Rabbani - Toxicology, 2000 - Elsevier
In this work we have attempted to characterize the programmed cell death (apoptosis) in
alveolar macrophages exposed to various concentrations of lead nitrate. It was found that …

The effect of lead acetate on oxidative stress and antioxidant status in rat bronchoalveolar lavage fluid and lung tissue

S Samarghandian, A Borji, R Afshari… - Toxicology …, 2013 - Taylor & Francis
Despite the wide spread of lead environmental pollution, the effect of this heavy metal on
respiratory disease was not shown yet. In respect to increased oxidative stress is an …

Gaseous nitrogen oxide repressed benzo [a] pyrene-induced human lung fibroblast cell apoptosis via inhibiting JNK1 signals

JH Chen, FP Chou, HH Lin, CJ Wang - Archives of toxicology, 2005 - Springer
Abstract Benzo [a] pyrene (B [a] P) is present in environmental pollution and cigarette
smoke. B [a] P has been shown to induce apoptosis in hepatoma cells, human B cells …

N-acetylcysteine alleviates pulmonary inflammatory response during benzo [a] pyrene-evoked acute lung injury

H Zhao, L Fu, HX Xiang, Y Xiang, MD Li, BB Lv… - … Science and Pollution …, 2022 - Springer
Abstract Benzo [a] pyrene (BaP), a representative polycyclic aromatic hydrocarbon, exists
widely in automobile emissions and polluted atmosphere. The current study aimed to …

[HTML][HTML] Low-dose combined exposure of carboxylated black carbon and heavy metal lead induced potentiation of oxidative stress, DNA damage, inflammation, and …

N Jiang, H Wen, M Zhou, T Lei, J Shen, D Zhang… - Ecotoxicology and …, 2020 - Elsevier
Black carbon (BC) and heavy metal lead (Pb), as typical components of atmospheric PM 2.5,
have been shown to cause a variety of adverse health effects. However, co-exposure to BC …

Nuclear Factor Kappa B: A Pro-Inflammatory, Transcription Factor− Mediated Signalling Pathway in Lung Carcinogenesis and Its Inhibition By Nonsteroidal Anti …

S Setia, SN Sanyal - Journal of Environmental Pathology …, 2012 - dl.begellhouse.com
Dimethyl benz (a) anthracene (DMBA), when injected intratracheally once at a dose of 20
mg/kg body weight, is found to induce lung cancer in rats. Two nonsteroidal anti …