Lung cancer associated with combustion particles and fine particulate matter (PM2. 5)-The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon …

JA Holme, J Vondráček, M Machala… - Biochemical …, 2023 - Elsevier
Air pollution is the leading cause of lung cancer after tobacco smoking, contributing to 20%
of all lung cancer deaths. Increased risk associated with living near trafficked roads …

Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer

R Stading, G Gastelum, C Chu, W Jiang… - Seminars in cancer …, 2021 - Elsevier
Lung cancer has the second highest incidence and highest mortality compared to all other
cancers. Polycyclic aromatic hydrocarbon (PAH) molecules belong to a class of compounds …

Aryl hydrocarbon receptor plays a significant role in mediating airborne particulate-induced carcinogenesis in mice

Y Matsumoto, F Ide, R Kishi, T Akutagawa… - … science & technology, 2007 - ACS Publications
Urban particulate air pollution is associated with an increased incidence of cancers, and
especially lung cancer. Organic extracts of airborne particulate matter (APM) cause cancer …

Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases

M Låg, J Øvrevik, M Refsnes, JA Holme - Respiratory research, 2020 - Springer
Epidemiological studies have found strong associations between air pollution and
respiratory effects including development and/or exacerbation of asthma and chronic …

Polycyclic aromatic hydrocarbons: from metabolism to lung cancer

B Moorthy, C Chu, DJ Carlin - Toxicological Sciences, 2015 - academic.oup.com
Excessive exposure to polycyclic aromatic hydrocarbons (PAHs) often results in lung cancer,
a disease with the highest cancer mortality in the United States. After entry into the lung …

Genotoxic potential of polycyclic aromatic hydrocarbons-coated onto airborne particulate matter (PM2. 5) in human lung epithelial A549 cells

S Billet, I Abbas, J Le Goff, A Verdin, V André… - Cancer Letters, 2008 - Elsevier
To improve the knowledge of the underlying mechanisms of action involved in air pollution
Particulate Matter (PM)-induced toxicity in human lungs, with a particular interest of the …

The carcinogenic properties of overlooked yet prevalent polycyclic aromatic hydrocarbons in human lung epithelial cells

AK Bauer, KJ Siegrist, M Wolff, L Nield, T Brüning… - Toxics, 2022 - mdpi.com
The WHO classified air pollution as a human lung carcinogen and polycyclic aromatic
hydrocarbons (PAHs) are components of both indoor (eg, tobacco smoke and cookstoves) …

Polycyclic aromatic hydrocarbons within airborne particulate matter (PM2.5) produced DNA bulky stable adducts in a human lung cell coculture model

I Abbas, G Garçon, F Saint‐Georges… - Journal of Applied …, 2013 - Wiley Online Library
To extend current knowledge on the underlying mechanisms of air pollution particulate
matter (PM2. 5)‐induced human lung toxicity, the metabolic activation of polycyclic aromatic …

Molecular markers associated with the biological response to aromatic hydrocarbons from urban air in humans

F Arenas-Huertero, E Apátiga-Vega… - Air Pollution: New …, 2011 - books.google.com
Morbidity and mortality attributable to air pollution continue to be a growing problem in
several parts of the world. Both epidemiologic and clinical studies have demonstrated a …

Environmentally prevalent polycyclic aromatic hydrocarbons can elicit co-carcinogenic properties in an in vitro murine lung epithelial cell model

AK Bauer, K Velmurugan, S Plöttner, KJ Siegrist… - Archives of …, 2018 - Springer
Low molecular weight (LMW) polycyclic aromatic hydrocarbons (PAH) are the most
abundant PAHs environmentally, occupationally, and are in cigarette smoke; however, little …