N6-methyladenosine modifications in maternal-fetal crosstalk and gestational diseases

S Wu, K Liu, B Zhou, S Wu - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
As a medium among pregnant women, environment and fetus, placenta owns powerful and
delicate epigenetic processes to regulate gene expression and maintain cellular …

N6-methyladenosine dynamics in placental development and trophoblast functions, and its potential role in placental diseases

S Wu, K Liu, Y Cui, B Zhou, H Zhao, X Xiao… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Abstract N6-methyladenosine (m6A) is the most abundant modification controlling RNA
metabolism and cellular functions, but its roles in placental development are still poorly …

Research progress on N6-methyladenosine in the human placenta

W Zhou, P Xue, Y Yang, L Xia, B Yu - Journal of Perinatal Medicine, 2022 - degruyter.com
Abstract Objectives N6-methyladenosine (m6A) is one of the most common epigenetic
modifications of eukaryotic RNA. Under the jointly reversible regulation of related enzymes …

N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition

Y Wu, X Xu, M Qi, C Chen, M Li, R Yan, X Kou… - Nature cell …, 2022 - nature.com
Abstract N 6-methyladenosine (m6A) and its regulatory components play critical roles in
various developmental processes in mammals. However, the landscape and function of …

Exploring the role of m6A modification in the great obstetrical syndromes

J Ning, J Yan, H Yang - The Journal of Maternal-Fetal & Neonatal …, 2023 - Taylor & Francis
Abstract Background N6-methyladenosine (m6A) is one of the predominant RNA epigenetic
modifications that modify RNAs reversibly and dynamically by “writers”(methyltransferase),“ …

[HTML][HTML] Epitranscriptomic profiling in human placenta: N6‐methyladenosine modification at the 5′‐untranslated region is related to fetal growth and preeclampsia

K Taniguchi, T Kawai, J Kitawaki, J Tomikawa… - The FASEB …, 2020 - ncbi.nlm.nih.gov
Intracellular mRNA levels are not always proportional to their respective protein levels,
especially in the placenta. This discrepancy may be attributed to various factors including …

Integrated analysis of the transcriptome-wide m6A methylome in preeclampsia and healthy control placentas

J Wang, F Gao, X Zhao, Y Cai, H Jin - PeerJ, 2020 - peerj.com
N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic mRNA and
potential regulatory functions of m6A have been shown by mapping the RNA m6A …

[HTML][HTML] N6-Methyladenosine modifications in the female reproductive system: Roles in gonad development and diseases

H Mu, H Li, Y Liu, X Wang, Q Mei… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m 6 A) is the most prevalent chemical modification in
eukaryotic messenger RNAs. By participating in various RNA-related bioprocesses …

RNA N6-methyladenosine modification in female reproductive biology and pathophysiology

E Huang, L Chen - Cell Communication and Signaling, 2023 - Springer
Gene expression and posttranscriptional regulation can be strongly influenced by epigenetic
modifications. N6-methyladenosine, the most extensive RNA modification, has been …

Reading and writing of mRNA m6A modification orchestrate maternal-to-zygotic transition in mice

W Zhu, Y Ding, J Meng, L Gu, W Liu, L Li, H Chen… - Genome Biology, 2023 - Springer
Abstract N6-methyladenosine (m6A) modification has been shown to regulate RNA
metabolism. Here, we investigate m6A dynamics during maternal-to-zygotic transition (MZT) …