The resistance of Staphylococcus aureus (S. aureus) to various antibiotics has increased
dramatically due to the misuse of antibiotics, and thus the development of new anti-infective …

The dramatic increase of methicillin-resistant Staphylococcus aureus (MRSA) poses a great
challenge to the treatment of Staphylococcus aureus (S. aureus) infections. Therefore, there …

Methicillin-resistant Staphylococcus aureus is one of the leading causes of community and
nosocomial infections, which has created the urgent need for innovative anti-infective agents …

Drug-resistant bacteria was the third leading cause of death worldwide in 2019, which
sounds like a cautionary note for global public health. Therefore, developing novel …

Staphylococcus aureus, especially drug-resistant S. aureus infections, is a worldwide
healthcare challenge. There is a growing focus on antivirulence therapy against S. aureus …

Antimicrobial resistance (AMR) is a global health threat. The dramatic increase of Methicillin-
resistant Staphylococcus aureus (MRSA) infections emphasizes the need to find new anti …

The increasing incidence of Streptococcus pneumoniae (S. pneumoniae) infection severely
threatened the global public heath, causing a significant fatality in immunocompromised …

The strategy of targeting virulence factor has received great attention as it barely develops
bacterial resistance. Sortase A (SrtA) and caseinolytic peptidase P (ClpP), as important …

Streptococcus pneumoniae is an important human pathogenic bacterium that can cause
various life-threatening infections. Pneumolysin (PLY), the pore-forming toxin that forms …

Aims Natural products have been used as potentially important sources of novel
antibacterials in combating pathogenic Staphylococcus aureus isolates, a major problem …