Intervertebral disc (IVD) degeneration is strongly associated with low back pain, a major
cause of disability worldwide. An in‐depth understanding of IVD cell physiology is required …

In vitro-expanded intervertebral disc (IVD) cells could be a source for disc repair. However,
IVD cell characterization still remains challenging and is demanded to detect phenotypical …

Low back pain is the leading cause of disability worldwide and in many patients the source
of pain can be attributed to pathological changes within the intervertebral disc (IVD). As …

Because low back pain is frequently a result of intervertebral disc degeneration (IVDD),
strategies to regenerate or repair the IVD are currently being investigated. Often, ex vivo disc …

Intervertebral disc (IVD) degeneration has been described as an aberrant, cell‐mediated,
age‐and genetics‐dependent molecular degeneration process, which can be accelerated …

Stem cell therapy, which promotes stem cells differentiation toward specialized cell types,
increases the resident population and production of extracellular matrix, and can be used to …

Disc degeneration is the most common cause of back pain in adults and has enormous
socioeconomic implications. Conservative management is ineffective in most cases, and …

Study Design. This is a laboratory-based study examining a novel in vitro culture system for
intervertebral disc tissue. Objectives. Address the hypothesis that “the novel culture system …

Resolution of intervertebral disc (IVD) degeneration-associated inflammation is a
prerequisite for tissue regeneration and could possibly be achieved by strategies ranging …

Injection of soluble cell signaling factors into degenerated intervertebral discs (IVDs) offers a
minimally invasive treatment that could limit the processes of degeneration by stimulating …