We examined whether impairment of intracellular Ca2+ homeostasis is related to poor
embryo development in in vitro-aged oocytes. We found that in vitro aging of mouse oocytes …

In vivo post‐ovulatory aging of oocytes significantly affects the development of oocytes and
embryos. Also, oocyte aging alters the regulation of the intracellular calcium concentration …

Aging of oocytes, being not fertilized after ovulation for a prolonged time, considerably
affects normal development of the fertilized oocyte. We examined effects of the aging on a …

Postovulatory aging of oocytes significantly affects embryonic development. Also, altered
Ca2+ oscillation patterns can be observed in fertilized, aged mouse oocytes. Because Ca2+ …

We have previously demonstrated that initiation of intracellular calcium ([Ca2+] i) oscillations
in mouse eggs signals activation or apoptotic death depending on the age of the eggs in …

Intracellular Ca2+ oscillations at fertilization are responsible for triggering egg activation.
The aim of this study was to examine the effect of the age of the oocyte donor and in-vitro …

We previously demonstrated in the mouse oocyte that in vivo postovulatory aging
significantly suppresses activity of the endoplasmic reticulum (ER) Ca 2+-ATPase (Igarashi …

STUDY QUESTION What are the precise patterns of calcium oscillations during the
fertilization of human oocytes matured either in vivo or in vitro or aged in vitro and what is the …

Mammalian oocytes undergo significant growth during oogenesis and experience extensive
cytoplasmic and nuclear modifications immediately before ovulation in a process commonly …

Oocyte quality is a key factor in determining embryo development; however, we have a poor
understanding of what constitutes oocyte quality or the mechanisms governing it …