Cerebral ischaemia is the most common cause of impaired brain function. Biologically active
peptides represent potential drugs for reducing the damage that occurs after ischaemia. The …

The Semax (Met-Glu-His-Phe-Pro-Gly-Pro) peptide is a synthetic melanocortin derivative
that is used in the treatment of ischemic stroke. Previously, studies of the molecular …

Brain stroke continues to claim the lives of million people every year. To build the effective
strategies for stroke treatment it is necessary to understand the neuroprotective mechanisms …

Background The nootropic neuroprotective peptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro)
has proved efficient in the therapy of brain stroke; however, the molecular mechanisms …

Due to its nootropic, neuroprotective, and immunomodulatory effects, the peptide Semax is
utilized in the treatment of ischemic stroke. Our earlier RNA-Seq analysis of the …

Our group has been systematically investigating the effects of the neuropeptide pituitary
adenylate-cyclase activating polypeptide (PACAP) on the ischemic brain. To do so, we have …

Glyprolines are Gly-Pro (GP)-or Pro-Gly (PG)-containing biogenic peptides. These peptides
can act as neutrophil chemoattractants, or atheroprotective, anticoagulant, and …

Ischemic stroke is an acute local decrease in cerebral blood flow due to a thrombus or
embolus. Of particular importance is the study of the genetic systems that determine the …

Brain ischemia, also termed cerebral ischemia, is a condition in which there is insufficient
blood flow to the brain to meet metabolic demand, leading to tissue death (cerebral …

Abstract Ischemia/reperfusion (I/R) is a common injury leading to ischemic stroke. At present,
I/R treatment remains limited, highlighting the urgent need for the discovery and …