Muscle atrophy is an active process controlled by specific transcriptional programs, in which
muscle mass is lost by increased protein degradation and/or decreased protein synthesis …

Injury to skeletal muscle, whether acute or chronic, triggers macrophage‐mediated innate
immunity in a manner which can be either beneficial or harmful for subsequent repair …

Skeletal muscle regeneration in normal and diseased muscle is regulated by multiple factors
and cells present in the injured muscle micro‐environment. In addition to muscle progenitor …

Although the cause of Duchenne muscular dystrophy (DMD) is known, the specific factors
that initiate and perpetuate disease progression are not well understood. We hypothesized …

Abstract Toll-like receptor 4 (TLR4) recognizes specific structural motifs associated with
microbial pathogens and also responds to certain endogenous host molecules associated …

Conditions characterized by muscle wasting such as cachexia and sarcopenia are
devastating at the individual level, and they place a profound burden on public health …

Duchenne muscular dystrophy (DMD) is characterized by chronic skeletal muscle necrosis,
leading to muscle regeneration failure and fibrosis. Although macrophages (MPs) are …

Duchenne muscular dystrophy is an incurable genetic disease that presents with skeletal
muscle weakness and chronic inflammation and is associated with early mortality. Indeed …

Skeletal muscle atrophy is a debilitating complication of many chronic disease states and
disuse conditions including denervation. However, molecular and signaling mechanisms of …

Skeletal muscle is able to restore contractile functionality after injury thanks to its ability to
regenerate. Following muscle necrosis, debris is removed by macrophages, and muscle …