The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease

V Giedraitis, J Sundelöf, MC Irizarry, N Gårevik… - Neuroscience …, 2007 - Elsevier
Amyloid-beta (Aβ) with 40 (Aβ40) and 42 (Aβ42) amino acids, the main components of
amyloid plaques in the Alzheimer's disease (AD) brain, can be measured in human …

Amyloid β 38, 40, and 42 species in cerebrospinal fluid: more of the same?

NS Schoonenboom, C Mulder… - Annals of …, 2005 - Wiley Online Library
Various C‐terminally truncated amyloid β peptides (Aβ) are linked to Alzheimer's disease
(AD) pathogenesis. Cerebrospinal fluid (CSF) concentrations of Aβ38, Aβ40, and Aβ42 were …

Cerebrospinal fluid A beta 1–40 peptides increase in Alzheimer's disease and are highly correlated with phospho-tau in control individuals

S Lehmann, J Dumurgier, X Ayrignac, C Marelli… - Alzheimer's research & …, 2020 - Springer
Background Amyloid pathology, which is one of the characteristics of Alzheimer's disease
(AD), results from altered metabolism of the beta-amyloid (Aβ) peptide in terms of synthesis …

The relationship of plasma Aβ levels to dementia in aging individuals with mild cognitive impairment

M Fei, W Jianghua, M Rujuan, Z Wei, W Qian - Journal of the neurological …, 2011 - Elsevier
Amyloid β (Aβ) peptides are important components of plaques in Alzheimer's disease (AD).
A decrease in the CSF concentration of Aβ40 and Aβ42 is a potential biomarker for incident …

No correlation between time-linked plasma and CSF Aβ levels

N Le Bastard, L Aerts, J Leurs, W Blomme… - Neurochemistry …, 2009 - Elsevier
Plasma β-amyloid protein (Aβ) isoforms are considered potential biomarkers for Alzheimer's
disease (AD) and dementia. The relation between plasma and cerebrospinal fluid (CSF) …

Amyloid β protein 1–40 and 1–42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease

PD Mehta, T Pirttila, BA Patrick, M Barshatzky… - Neuroscience …, 2001 - Elsevier
We quantitated amyloid β proteins 1–40 (Aβ40) and 1–42 (Aβ42), and α1-antichymotrypsin
(ACT) in matched cerebrospinal fluid (CSF) and plasma of 50 patients with probable …

Plasma amyloid-β (Aβ 42) correlates with cerebrospinal fluid Aβ 42 in Alzheimer's disease

CE Teunissen, MJ Chiu, CC Yang… - Journal of …, 2018 - content.iospress.com
The 42 amino acid form of amyloid-ß (Aß42) plays a key role in the pathogenesis of
Alzheimer's disease (AD) and is a core biomarker for the diagnosis of AD. Numerous studies …

Is plasma amyloid-β 1–42/1–40 a better biomarker for Alzheimer's disease than AβX–42/X–40?

HW Klafki, B Morgado, O Wirths, O Jahn… - Fluids and Barriers of …, 2022 - Springer
Background A reduced amyloid-β (Aβ) 42/40 peptide ratio in blood plasma represents a
peripheral biomarker of the cerebral amyloid pathology observed in Alzheimer's disease …

Plaque‐associated disruption of CSF and plasma amyloid‐β (Aβ) equilibrium in a mouse model of Alzheimer's disease

RB DeMattos, KR Bales, M Parsadanian… - Journal of …, 2002 - Wiley Online Library
To better understand amyloid‐β (Aβ) metabolism in vivo, we assessed the concentration of
Aβ in the CSF and plasma of APPV717F (PDAPP) transgenic mice, a model that develops …

Increased cerebrospinal fluid Aβ38/Aβ42 ratio in Alzheimer disease

PD Mehta, T Pirttila - Neurodegenerative Diseases, 2006 - karger.com
We quantitated amyloid β peptide (Aβ) 38, Aβ40 and Aβ42 levels in matched CSF and
plasma from Alzheimer disease (AD) patients and controls. CSF Aβ38 and Aβ40 levels were …