Bayesian test for colocalisation between pairs of genetic association studies using summary statistics
Genetic association studies, in particular the genome-wide association study (GWAS)
design, have provided a wealth of novel insights into the aetiology of a wide range of human …
design, have provided a wealth of novel insights into the aetiology of a wide range of human …
Multiple phenotype association tests using summary statistics in genome‐wide association studies
We study in this article jointly testing the associations of a genetic variant with correlated
multiple phenotypes using the summary statistics of individual phenotype analysis from …
multiple phenotypes using the summary statistics of individual phenotype analysis from …
A unified framework for association analysis with multiple related phenotypes
M Stephens - PloS one, 2013 - journals.plos.org
We consider the problem of assessing associations between multiple related outcome
variables, and a single explanatory variable of interest. This problem arises in many settings …
variables, and a single explanatory variable of interest. This problem arises in many settings …
Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers
J Jakobsdottir, MB Gorin, YP Conley, RE Ferrell… - PLoS …, 2009 - journals.plos.org
Recent successful discoveries of potentially causal single nucleotide polymorphisms (SNPs)
for complex diseases hold great promise, and commercialization of genomics in …
for complex diseases hold great promise, and commercialization of genomics in …
A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits
Genome-wide association studies (GWAS) have identified thousands of genomic regions
affecting complex diseases. The next challenge is to elucidate the causal genes and …
affecting complex diseases. The next challenge is to elucidate the causal genes and …
Gene-based tests of association
Genome-wide association studies (GWAS) are now used routinely to identify SNPs
associated with complex human phenotypes. In several cases, multiple variants within a …
associated with complex human phenotypes. In several cases, multiple variants within a …
Introduction to genetic association studies
Genetic association studies are used to find candidate genes or genome regions that
contribute to a specific disease by testing for a correlation between disease status and …
contribute to a specific disease by testing for a correlation between disease status and …
Informed conditioning on clinical covariates increases power in case-control association studies
Genetic case-control association studies often include data on clinical covariates, such as
body mass index (BMI), smoking status, or age, that may modify the underlying genetic risk …
body mass index (BMI), smoking status, or age, that may modify the underlying genetic risk …
Association study designs for complex diseases
Assessing the association between DNA variants and disease has been used widely to
identify regions of the genome and candidate genes that contribute to disease. However …
identify regions of the genome and candidate genes that contribute to disease. However …
Enriching the analysis of genomewide association studies with hierarchical modeling
Genomewide association studies (GWAs) initially investigate hundreds of thousands of
single-nucleotide polymorphisms (SNPs), and the most promising SNPs are further …
single-nucleotide polymorphisms (SNPs), and the most promising SNPs are further …