Increased serum levels of IL-15 are reported in type 1 diabetes (T1D). Here we report
elevated serum soluble IL-15Rα levels in human T1D. To investigate the role of IL-15/IL …

Abstract Aims/hypothesis IL-15, induced by innate immune stimuli, promotes rheumatoid
arthritis and inflammatory bowel disease. However, its role in autoimmune type 1 diabetes is …

IL-15 is a 14–15kD cytokine produced by monocytes/macrophages and shares some
biological actions with IL-2. The serum concentration of IL-15 in type 1 diabetic patients has …

We have shown that pathogenic T helper type 17 (Th17) cells differentiated from naive
CD4+ T cells of BDC2· 5 T cell receptor transgenic non-obese diabetic (NOD) mice by …

OBJECTIVE Interleukin (IL)-21 is a type 1 cytokine that has been implicated in the
pathogenesis of type 1 diabetes via the unique biology of the nonobese diabetic (NOD) …

Interleukin (IL)-17A, a proinflammatory cytokine produced by T-helper (Th) 17 cells, has
been associated with autoimmune diseases. Type 1 diabetes (T1D) is caused either due to …

Abstract Interleukin-15 (IL-15) is a pro-inflammatory cytokine that is required for the survival
and activation of memory CD8+ T cells, natural killer (NK) cells, innate lymphoid cells …

IL-21 is a pleiotropic type I cytokine that shares the common cytokine receptor γ chain and
plays important roles for normal Ig production, terminal B cell differentiation to plasma cells …

OBJECTIVE CD4 T-cells secreting interleukin (IL)-17 are implicated in several human
autoimmune diseases, but their role in type 1 diabetes has not been defined. To address the …

Th17 immunity has been shown to regulate autoimmune diabetes in mice. IL-17
neutralization prevented development of diabetes when given postinitiation of insulitis but …