The historical impression that tuberculosis was an inherited disorder has come full circle and
substantial evidence now exists of the human genetic contribution to susceptibility to …

The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …

Familial risk of tuberculosis (TB) has been recognized for centuries. Largely through studies
of mono-and dizygotic twin concordance rates, studies of families with Mendelian …

Host genetic factors are important in determining susceptibility to Mycobacterium
tuberculosis. Genome-wide linkage studies have been performed in humans and in murine …

Convincing evidence exists that host genes influence the outcome of infection in human
tuberculosis. We are employing two complementary strategies to find the genes involved, a …

Several candidate gene studies have provided evidence for a role of host genetics in
susceptibility to tuberculosis (TB). However, the results of these studies have been very …

Abstract Purpose of Review Tuberculosis (TB), caused by Mycobacterium tuberculosis
(MTB), remains a major public health threat globally. Several lines of evidence support a …

The molecular basis of genetic predisposition to pulmonary tuberculosis in adults remains
largely elusive. Few candidate genes have consistently been implicated in tuberculosis …

Early observations, candidate gene studies and, more recently, genome-wide association
studies have shown that susceptibility to tuberculosis has a host genetic component …

The genetics underlying tuberculosis (TB) pathophysiology are poorly understood. Human
genome-wide association studies have failed so far to reveal reproducible susceptibility loci …