Cyclic pentapeptide Tyr-c [D-Lys-Phe-Phe-Asp] NH 2, based on the structure of
endomorphin-2 (EM-2), which shows high affinity to the μ-opioid receptor (MOR) and a very …

In our previous paper we have reported the synthesis and biological activity of a cyclic
analog, Tyr-c (D-Lys-Phe-Phe-Asp)-NH2, based on endomorphin-2 (EM-2) structure. This …

As part of our continuing studies on the structure–activity relationships of cyclic
pentapeptides based on the structure of endomorphin-2, we report here the synthesis and …

This study reports the synthesis and biological evaluation of a series of new side-chain-to-
side-chain cyclized endomorphin-2 (EM-2) and morphiceptin analogs of a general structure …

The study reports the synthesis and biological evaluation of two opioid analogs, a monomer
and a dimer, obtained as products of the solid‐phase, side‐chain to side‐chain cyclization of …

Cyclic analogs of the opioid peptides endomorphin-2 and morphiceptin of the type Tyr-X-
Phe-Phe-Y-NH2 and Tyr-X-Phe-d-Pro-Y-NH2 (X= Lys or Asp and Y= Lys or Asp) …

The study reports the solid-phase synthesis and biological evaluation of a series of new side
chain-to-side chain cyclized opioid peptide analogs of the general structure Tyr-[D-Xaa-Phe …

An ultimate and general model describing the interaction between opioid ligands and μ-
opioid receptors is not available yet, so the mode of action of atypical peptide analogues or …

A series of position 4‐substituted endomorphin‐2 (Tyr‐Pro‐Phe‐Phe‐NH2) analogs
containing 3‐(1‐naphthyl)‐alanine (1‐Nal) or 3‐(2‐naphthyl)‐alanine (2‐Nal) in l‐or d …

Endogenous μ-opioid receptor (MOR) selective peptides, endomorphin-1 (EM-1) and
endomorphin-2 (EM-2), unlike so called 'typical opioids', are characterized by the presence …