The cellular adaptive response to hypoxia relies on the expression of hypoxia-inducible
factors (HIFs), HIF-1 and HIF-2. HIFs regulate global gene expression changes during …

The cellular adaptation to hypoxia is regulated by hypoxia inducible factors: HIF-1 and HIF-
2. HIF-1 mediates response to acute hypoxia, whereas HIF-2 allows adaptation to chronic …

The decline of oxygen tension in the tissues below the physiological demand leads to the
hypoxic adaptive response. This physiological consequence enables cells to recover from …

Abstract Hypoxia-inducible factors (HIFs) 1 and 2 are dimeric α/β transcription factors that
regulate cellular responses to low oxygen. HIF-1 is induced first, whereas HIF-2 is …

Solid tumor microenvironments are often subjected to various levels of hypoxia. Although
regulation of gene expression has been examined extensively, most studies have focused …

Adaptation to hypoxia is an essential cellular response controlled by the oxygen-sensitive
master transcription factor hypoxia-inducible factor 1 (HIF-1). HIF-1 expression is also …

HRMs (hypoxia-responsive miRNAs) are a specific group of microRNAs that are regulated
by hypoxia. Recent studies revealed that several HRMs including let-7 family miRNAs were …

Adaptive changes to oxygen availability are critical for cell survival and tissue homeostasis.
Prolonged oxygen deprivation due to reduced blood flow to cardiac or peripheral tissues …

Hypoxia-inducible factors (HIF) are heterodimeric transcription factors that allow cells to
adapt and survive during hypoxia. Regulation of HIF1A and HIF2A mRNA is well …

The hypoxia-inducible factor (HIF) is a key regulator of the transcriptional response to
hypoxia. While the mechanism underpinning HIF activation is well understood, little is known …