Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments
Accumulation of trimethylation of histone H3 at lysine 4 (H3K4me3) on immune-related gene
promoters underlies robust transcription during trained immunity. However, the molecular …
promoters underlies robust transcription during trained immunity. However, the molecular …
The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4
V Ranzani, G Rossetti, I Panzeri, A Arrigoni… - Nature …, 2015 - nature.com
Long noncoding RNAs are emerging as important regulators of cellular functions, but little is
known of their role in the human immune system. Here we investigated long intergenic …
known of their role in the human immune system. Here we investigated long intergenic …
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation
Although intergenic long noncoding RNAs (lincRNAs) have been linked to gene regulation
in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here …
in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here …
[HTML][HTML] Advances in understanding molecular regulation of innate immune memory
The epigenetic and functional reprogramming of immune genes during induction of trained
immunity is accompanied by the metabolic rewiring of cellular state. This memory is induced …
immunity is accompanied by the metabolic rewiring of cellular state. This memory is induced …
Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression
Innate lymphoid cells (ILCs) communicate with other hematopoietic and nonhematopoietic
cells to regulate immunity, inflammation and tissue homeostasis. How ILC lineages develop …
cells to regulate immunity, inflammation and tissue homeostasis. How ILC lineages develop …
The how and why of lncRNA function: an innate immune perspective
EK Robinson, S Covarrubias, S Carpenter - Biochimica et Biophysica Acta …, 2020 - Elsevier
Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …
Local regulation of gene expression by lncRNA promoters, transcription and splicing
Mammalian genomes are pervasively transcribed, to produce thousands of long non-coding
RNAs (lncRNAs),. A few of these lncRNAs have been shown to recruit regulatory complexes …
RNAs (lncRNAs),. A few of these lncRNAs have been shown to recruit regulatory complexes …
A long noncoding RNA mediates both activation and repression of immune response genes
An inducible program of inflammatory gene expression is central to antimicrobial defenses.
This response is controlled by a collaboration involving signal-dependent activation of …
This response is controlled by a collaboration involving signal-dependent activation of …
[HTML][HTML] Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes
Early reports indicate that long non-coding RNAs (lncRNAs) are novel regulators of
biological responses. However, their role in the human innate immune response, which …
biological responses. However, their role in the human innate immune response, which …
[HTML][HTML] The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
S Agarwal, T Vierbuchen, S Ghosh, J Chan… - Nature …, 2020 - nature.com
Long non-coding RNAs are important regulators of biological processes including immune
responses. The immunoregulatory functions of lncRNAs have been revealed primarily in …
responses. The immunoregulatory functions of lncRNAs have been revealed primarily in …