Hydrogen peroxide induces the activation of the phospholipase C-γ1 survival pathway in PC12 cells: protective role in apoptosis

W Yuan, J Guo, X Li, Z Zou, G Chen, J Sun… - Acta Biochim …, 2009 - academic.oup.com
It has been reported that phospholipase C-γ1 (PLC-γ1) plays an important protective role in
hydrogen peroxide (H2O2)-induced pheochromocytoma (PC) 12 cells death. However, most …

Phospholipase C-γ1 is required for cell survival in oxidative stress by protein kinase C

XC Bai, F Deng, AL Liu, ZP Zou, Y Wang… - Biochemical …, 2002 - portlandpress.com
Phospholipase C-γ1 (PLC-γ1) activation has been reported to enhance cell survival during
the cellular response to oxidative stress. We studied the role of protein kinase C (PKC) …

Overexpression of phospholipase Cβ-1 protects NIH3T3 cells from oxidative stress-induced cell death

YH Lee, SY Kim, JR Kim, KT Yoh, SH Baek, MJ Kim… - Life Sciences, 2000 - Elsevier
Oxidative stress has been implicated in a wide range of cellular damage which includes
DNA oxidation, membrane lipid peroxidation, and apoptosis. In our study, we found that …

Catalpol inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade

B Jiang, JH Liu, YM Bao, LJ An - Toxicon, 2004 - Elsevier
In the present study, using a rat pheochromocytoma (PC12) cell line, the effect of catalpol on
H2O2-induced apoptosis was studied. The apoptosis in H2O2-induced PC12 cells was …

Salidroside inhibits H2O2‐induced apoptosis in PC 12 cells by preventing cytochrome c release and inactivating of caspase cascade

L Cai, H Wang, Q Li, Y Qian… - Acta biochimica et …, 2008 - Wiley Online Library
We used a rat pheochromocytoma (PC 12) cell line to study the effects of salidroside on
hydrogen peroxide (H2O2)‐induced apoptosis. In PC12 cells, H2O2‐induced apoptosis was …

Bcl-2 switches the type of demise from apoptosis to necrosis via cyclooxygenase-2 upregulation in HeLa cell induced by hydrogen peroxide

GJ Du, HH Lin, QT Xu, MW Wang - Cancer Letters, 2006 - Elsevier
Bcl-2 is best known for its anti-apoptotic function in a wide variety of cell types. The objective
of this study was to investigate the effects of bcl-2 on the types of cell demise in the HeLa/bcl …

Phospholipase D2 activity suppresses hydrogen peroxide‐induced apoptosis in PC12 cells

SD Lee, BD Lee, JM Han, JH Kim, Y Kim… - Journal of …, 2000 - Wiley Online Library
Phospholipase D (PLD) plays an important role as an effector in the membrane lipid‐
mediated signal transduction. However, the precise physiological functions of PLD are not …

Overexpression of phospholipase C-γ1 suppresses UVC-induced apoptosis through inhibition of c-fos accumulation and c-Jun N-terminal kinase activation in PC12 …

YH Lee, SY Kim, JR Kim, KY Kim, MJ Kim… - … et Biophysica Acta (BBA …, 1999 - Elsevier
Ultraviolet-C (UVC) irradiation induces DNA damage and UVC-irradiated cells undergo cell
growth arrest to repair the damaged DNA or the induction of apoptosis to prevent the risk of …

Regulation of bcl-2 family in hydrogen peroxide-induced apoptosis in human leukemia HL-60 cells

JE Lee, J Sohn, JH Lee, KC Lee, CS Son… - … & Molecular Medicine, 2000 - nature.com
Numerous types of cells have been shown to undergo apoptosis when exposed to oxidant
agent such as hydrogen peroxide. In order to understand the functional relationship …

Proteolytic cleavage of phospholipase C–γ1 during apoptosis in Molt–4 cells

SS Bae, DK Perry, YS Oh, JH Choi… - The FASEB …, 2000 - Wiley Online Library
Apoptosis is a cell suicide mechanism that requires the activation of cellular death proteases
for its induction. We examined whether the progress of apoptosis involves cleavage of …