Understanding brain structures and circuits impacted by alcohol use disorder is critical for
improving our future prevention techniques and treatment options. A brain region that has …

How does binge drinking alcohol change synaptic function, and do these changes maintain
binge consumption? The anterior insular cortex (AIC) and dorsolateral striatum (DLS) are …

Humans with alcohol use disorder typically abstain because of the negative consequences
associated with excessive drinking, and exposure to contexts previously associated with …

Internal drug states/cues can impact drug taking, as pretreatment with a moderate to high
alcohol dose (ie, loading dose) can decrease subsequent alcohol self-administration …

Rationale Insular cortex supports the representation of motivational feelings through the
integration of interoceptive information concerning bodily physiology. Compromised insular …

Brain lesions that damage the insular cortex (IC) interrupt addictive behaviors, suggesting
that drug addiction sensitizes the insula. However, neuroimaging studies seem to lead to an …

The insular cortex (IC) is a region proposed to modulate, in part, interoceptive states and
motivated behavior. Interestingly, IC dysfunction and deficits in interoceptive processing are …

Excessive use of alcohol promotes the development of alcohol addiction, but the
understanding of how alcohol-induced brain alterations lead to addiction remains limited. To …

Alcohol use disorder is a complex psychiatric disorder that can be modeled in rodents using
a number of drinking paradigms. Drinking-in-the-dark (DID) is widely used to model the …

An emergent literature suggests that resting state functional magnetic resonance imaging
(rsfMRI) functional connectivity (FC) patterns are aberrant in alcohol use disorder (AUD) …