It was shown recently that exposure of the developing rat brain during the peak of
synaptogenesis to commonly used general anesthetics can trigger widespread apoptotic …

Rapidly accumulating evidence indicates that clinically used general anesthesia causes
massive, widespread neuroapoptotic degeneration in the developing mammalian brain …

Anesthetic-induced neurodegeneration in the developing brain has been well documented.
However, the experiments carried out so far do not include surgical conditions. This proof of …

Eight years ago, Ikonomidou et al. 1 reported that treatment of infant rats with drugs that
block N-methyl-d-aspartate (NMDA) glutamate receptors causes widespread apoptotic …

Common general anesthetics administered to young rats at the peak of brain development
cause widespread apoptotic neurodegeneration in their immature brain. Behavioral studies …

Background General anaesthesia facilitates surgical operations and painful interventions in
millions of patients every year. Recent observations of anaesthetic-induced neuronal cell …

Exposure of the immature brain to general anesthesia is common. The safety of this practice
has recently been challenged in view of evidence that general anesthetics can damage …

Frequent exposure of children to general anesthesia is common practice in modern
medicine. Although previously unrecognized, recent in vitro and in vivo animal studies …

BACKGROUND: Accumulating evidence indicates that isoflurane and other, similarly acting
anesthetics exert neurotoxic effects in neonatal animals. However, neither the identity of …

Objective Anesthetics have been linked to widespread neuronal cell death in neonatal
animals. Epidemiological human studies have associated early childhood anesthesia with …