Polycomb-dependent histone H2A ubiquitination links developmental disorders with cancer
Cell identity is tightly controlled by specific transcriptional programs which require post-
translational modifications of histones. These histone modifications allow the establishment …
translational modifications of histones. These histone modifications allow the establishment …
[HTML][HTML] Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
Histone posttranslational modifications are key regulators of chromatin-associated
processes including gene expression, DNA replication and DNA repair. Monoubiquitinated …
processes including gene expression, DNA replication and DNA repair. Monoubiquitinated …
PR-DUB maintains the expression of critical genes through FOXK1/2-and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination
Polycomb group proteins are important for maintaining gene expression patterns and cell
identity in metazoans. The mammalian Polycomb repressive deubiquitinase (PR-DUB) …
identity in metazoans. The mammalian Polycomb repressive deubiquitinase (PR-DUB) …
[PDF][PDF] Histone H2AK119 mono-ubiquitination is essential for polycomb-mediated transcriptional repression
S Tamburri, E Lavarone, D Fernández-Pérez… - Molecular cell, 2020 - cell.com
Polycomb group proteins (PcGs) maintain transcriptional repression to preserve cellular
identity in two distinct repressive complexes, PRC1 and PRC2, that modify histones by …
identity in two distinct repressive complexes, PRC1 and PRC2, that modify histones by …
Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase
Repression of gene expression by protein complexes of the Polycomb group is a
fundamental mechanism that governs embryonic development and cell-type specification …
fundamental mechanism that governs embryonic development and cell-type specification …
Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1
Histone H2A lysine 119 (H2AK119Ub) is monoubiquitinated by Polycomb repressive
complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex (PR-DUB) …
complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex (PR-DUB) …
[HTML][HTML] Histone monoubiquitination in chromatin remodelling: focus on the histone H2B interactome and cancer
DJ Marsh, Y Ma, KA Dickson - Cancers, 2020 - mdpi.com
Simple Summary Post-translational modifications (PTM) of histone tails represent
epigenomic regulation of the chromatin landscape, influencing gene expression and the …
epigenomic regulation of the chromatin landscape, influencing gene expression and the …
PR‐DUB safeguards Polycomb repression through H2AK119ub1 restriction
R Li, D Huang, Y Zhao, Y Yuan, X Sun, Z Dai… - Cell …, 2023 - Wiley Online Library
Polycomb group (PcG) proteins are critical chromatin regulators for cell fate control. The
mono‐ubiquitylation on histone H2AK119 (H2AK119ub1) is one of the well‐recognized …
mono‐ubiquitylation on histone H2AK119 (H2AK119ub1) is one of the well‐recognized …
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes
Polycomb group (PcG) proteins function as chromatin-based transcriptional repressors that
are essential for normal gene regulation during development. However, how these systems …
are essential for normal gene regulation during development. However, how these systems …
[HTML][HTML] Histone mono-ubiquitination in transcriptional regulation and its mark on life: emerging roles in tissue development and disease
L Oss-Ronen, T Sarusi, I Cohen - Cells, 2022 - mdpi.com
Epigenetic regulation plays an essential role in driving precise transcriptional programs
during development and homeostasis. Among epigenetic mechanisms, histone mono …
during development and homeostasis. Among epigenetic mechanisms, histone mono …