Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent
amplifications in oncogenes. However, the mechanisms leading to amplicons that involve …

Central to tumor evolution is the generation of genetic diversity. However, the extent and
patterns by which de novo karyotype alterations emerge and propagate within human …

Organoid evolution models complemented with integrated single-cell sequencing
technology provide a powerful platform to characterize intra-tumor heterogeneity (ITH) and …

The classic tumor clonal evolution theory postulates that cancers change over time to
produce unique molecular subclones within a parent neoplasm, presumably including …

It is possible to decipher the clonal architecture of a tumor and the sequence in which cancer
clones acquire genomic alterations through multiregion sequencing (M-seq). Serial …

Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies,
but little is known about its spatial intratumoral heterogeneity (ITH) and temporal clonal …

Focal oncogene amplification and rearrangements drive tumor growth and evolution in
multiple cancer types. We present AmpliconArchitect (AA), a tool to reconstruct the fine …

Cancers develop and progress as mutations accumulate, and with the advent of single-cell
DNA and RNA sequencing, researchers can observe these mutations and their …

Extrachromosomal DNA (ecDNA) amplification promotes high oncogene copy number,
intratumoral genetic heterogeneity, and accelerated tumor evolution–, but its frequency and …

In a recent issue of Cell, Yang et al. utilize evolvable cellular barcodes to investigate the
evolutionary trajectories of murine lung adenocarcinoma. Reconstructing the life histories of …