[HTML][HTML] Post-marketing surveillance of CAR-T-cell therapies: Analysis of the FDA adverse event reporting system (FAERS) database
M Fusaroli, V Isgrò, PM Cutroneo, C Ferrajolo, V Cirillo… - Drug Safety, 2022 - Springer
Introduction As chimeric antigen receptor T-cell therapies are becoming increasingly
available in the armamentarium of the hematologist, there is an emerging need to monitor …
available in the armamentarium of the hematologist, there is an emerging need to monitor …
Chimeric antigen receptor T‐cells safety: A pharmacovigilance and meta‐analysis study
C Dolladille, S Ederhy, E Ezine… - American Journal of …, 2021 - Wiley Online Library
Chimeric‐antigen‐receptor T cells directed against CD19 (CAR‐T) are emerging
hematological therapeutics with scarce data on its overall safety profile spectrum. To …
hematological therapeutics with scarce data on its overall safety profile spectrum. To …
[HTML][HTML] Cardiovascular events associated with chimeric antigen receptor T cell therapy: cross-sectional FDA adverse events reporting system analysis
Chimeric antigen receptor (CAR) T cell therapy is approved in the United States for the
treatment of acute lymphocytic leukemia and aggressive B cell lymphomas. Multiple …
treatment of acute lymphocytic leukemia and aggressive B cell lymphomas. Multiple …
[HTML][HTML] Hemophagocytic lymphohistiocytosis and disseminated intravascular coagulation are underestimated, but fatal adverse events in chimeric antigen receptor T …
Z Song, D Tu, G Tang, N Liu, Z Tai, J Yang… - Haematologica, 2023 - ncbi.nlm.nih.gov
Hematotoxicity is the most common long-term adverse event (AE) after chimeric antigen
receptor T-cell (CAR T) therapy. However, patients who receive CAR T therapy in pivotal …
receptor T-cell (CAR T) therapy. However, patients who receive CAR T therapy in pivotal …
[HTML][HTML] The pathogenesis, diagnosis, prevention, and treatment of CAR-T cell therapy-related adverse reactions
Y Li, Y Ming, R Fu, C Li, Y Wu, T Jiang, Z Li… - Frontiers in …, 2022 - frontiersin.org
Chimeric antigen receptor (CAR)-T cell therapy is effective in the treatment of
refractory/relapsed (r/r) hematological malignancies (r/r B-cell lymphoblastic leukemia, B-cell …
refractory/relapsed (r/r) hematological malignancies (r/r B-cell lymphoblastic leukemia, B-cell …
Adverse cardiovascular and pulmonary events associated with chimeric antigen receptor T-cell therapy
Background Pivotal trials of chimeric antigen receptor T-cell (CAR-T) have identified
common toxicities but may have been underpowered to detect cardiovascular and …
common toxicities but may have been underpowered to detect cardiovascular and …
[HTML][HTML] Thrombotic events are unusual toxicities of chimeric antigen receptor T-cell therapies
C Schorr, J Forindez, M Espinoza-Gutarra… - International Journal of …, 2023 - mdpi.com
Chimeric antigen receptor (CAR) T-cell therapy has greatly transformed the treatment and
prognosis of B-cell hematological malignancies. As CAR T-cell therapy continues to be more …
prognosis of B-cell hematological malignancies. As CAR T-cell therapy continues to be more …
[HTML][HTML] Mechanisms and management of chimeric antigen receptor T-cell therapy-related toxicities
BR Dholaria, CA Bachmeier, F Locke - BioDrugs, 2019 - Springer
Chimeric antigen receptor T-cell (CAR-T) therapy has proven to be a very effective cancer
immunotherapy. Axicabtagene ciloleucel and tisagenlecleucel are the first-in-class anti …
immunotherapy. Axicabtagene ciloleucel and tisagenlecleucel are the first-in-class anti …
Real-world adverse events associated with CAR T-cell therapy among adults age≥ 65 years
ME Zettler, BA Feinberg, EG Phillips Jr, AJ Klink… - Journal of Geriatric …, 2021 - Elsevier
Introduction Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising
treatment for relapsed or refractory large B-cell lymphoma (LBCL) with the Food and Drug …
treatment for relapsed or refractory large B-cell lymphoma (LBCL) with the Food and Drug …
[HTML][HTML] Chimeric antigen receptor-T cell therapy: practical considerations for implementation in Europe
J Buechner, MJ Kersten, M Fuchs, F Salmon… - HemaSphere, 2018 - journals.lww.com
Chimeric antigen receptor (CAR)-T cell therapy is a new class of cellular immunotherapies
that involves ex vivo genetic modification of T cells to incorporate an engineered CAR. After …
that involves ex vivo genetic modification of T cells to incorporate an engineered CAR. After …