Objective Midlife vascular risk factors (MVRFs) are associated with incident dementia, as are
amyloid β (Aβ) deposition and neurodegeneration. Whether vascular and Alzheimer disease …

Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

Introduction Little is known about how antecedent vascular risk factor (VRF) profiles impact
late‐life brain health. Methods We examined baseline VRFs, and cognitive testing and …

Objective Elevated vascular risk and beta‐amyloid (Aβ) burden have been synergistically
associated with cognitive decline in preclinical Alzheimer's disease (AD), although the …

Vascular factors are now established risk factors for cognitive decline, both for dementia and
its two main subtypes: Alzheimer's disease (AD) and vascular dementia. Their impact likely …

Importance Midlife vascular risk factors have been associated with late-life dementia.
Whether these risk factors directly contribute to brain amyloid deposition is less well …

Objective To determine whether vascular and neurodegenerative factors influence cognition
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …

Background: Cardiovascular disease (CVD) and related risk factors are associated with
Alzheimer's disease (AD). This association is less well-defined in normal cognition (NC) or …

Importance Vascular risk factors have been associated with cognitive decline. Midlife
exposure to these factors may be most important in conferring late-life risk of cognitive …

Objective To determine whether vascular risk and Alzheimer disease (AD) biomarkers have
independent or synergistic effects on cognitive decline and whether vascular risk is …