The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables
the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might …

ATP is the dominant energy source in animals for mechanical and electrical work (for
example, muscle contraction or neuronal firing). For chemical work, there is an equally …

One-carbon metabolism is a central metabolic hub that provides one-carbon units for
essential biosynthetic reactions and for writing epigenetics marks. The leading role in this …

One-carbon metabolism is an essential branch of cellular metabolism that intersects with
epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit …

Reactive aldehydes are common carcinogens. They are also by-products of several
metabolic pathways and, without enzymatic catabolism, may accumulate and cause DNA …

Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that
can damage DNA. Here we report a synthetic lethal interaction in avian cells between …

Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol
consumption. Impaired detoxification of acetaldehyde is common in the Asian population …

Formaldehyde (FA) is a ubiquitous endogenous and environmental metabolite that is
thought to exert cytotoxicity through DNA and DNA-protein crosslinking, likely contributing to …

Endogenous formaldehyde is produced by numerous biochemical pathways fundamental to
life, and it can crosslink both DNA and proteins. However, the consequences of its …

Cancer cells fuel their increased need for nucleotide supply by upregulating one-carbon
(1C) metabolism, including the enzymes methylenetetrahydrofolate dehydrogenase …