[HTML][HTML] Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer

C Martini, JM Logan, A Sorvina, C Gordon, AR Beck… - Pathology, 2023 - Elsevier
Diagnosis and assessment of patients with prostate cancer is dependent on accurate
interpretation and grading of histopathology. However, morphology does not necessarily …

[HTML][HTML] Appl1, Sortilin and Syndecan-1 immunohistochemistry on intraductal carcinoma of the prostate provides evidence of retrograde spread

A Sorvina, C Martini, S Prabhakaran, JM Logan… - Pathology, 2023 - Elsevier
The presence of intraductal carcinoma of the prostate (IDCP) correlates with late-stage
disease and poor outcomes for patients with prostatic adenocarcinoma, but the accurate and …

Pathology-driven comprehensive proteomic profiling of the prostate cancer tumor microenvironment

L Staunton, C Tonry, R Lis, V Espina, L Liotta… - Molecular Cancer …, 2017 - AACR
Prostate cancer is the second most common cancer in men worldwide. Gleason grading is
an important predictor of prostate cancer outcomes and is influential in determining patient …

Prediction of prostate cancer biochemical and clinical recurrence is improved by IHC-assisted grading using Appl1, Sortilin and Syndecan-1

JM Logan, AM Hopkins, C Martini, A Sorvina, P Tewari… - Cancers, 2023 - mdpi.com
Simple Summary A novel biomarker panel (Appl1, Sortilin and Syndecan-1) was
demonstrated as a strong independent predictor for both clinical and biochemical …

Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression

J Lazniewska, KL Li, IRD Johnson, A Sorvina… - Scientific reports, 2023 - nature.com
Prostate cancer (PCa) development and progression relies on the programming of glucose
and lipid metabolism, and this involves alterations in androgen receptor expression and …

Novel histopathological biomarkers in prostate cancer: implications and perspectives

P Kiełb, K Kowalczyk, A Gurwin, Ł Nowak, W Krajewski… - Biomedicines, 2023 - mdpi.com
Prostate cancer (PCa) is the second most frequently diagnosed cancer in men. Despite the
significant progress in cancer diagnosis and treatment over the last few years, the approach …

[HTML][HTML] Five-gene signature associating with Gleason score serve as novel biomarkers for identifying early recurring events and contributing to early diagnosis for …

L Zhang, Y Li, X Wang, Y Ping, D Wang, Y Cao… - Journal of …, 2021 - ncbi.nlm.nih.gov
Background: Compared to non-recurrent type, recurrent prostate adenocarcinoma (PCa) is
highly fatal, and significantly shortens the survival time of affected patients. Early and …

Biomarker expression patterns that correlate with high grade features in treatment naive, organ-confined prostate cancer

TJ McDonnell, NS Chari, JH Cho-Vega… - BMC medical …, 2008 - Springer
Background: The early detection of prostate cancer has resulted in an increase in the
number of patients with localized prostate cancer and has paralleled the reported reduction …

Novel biomarkers for prostate cancer including noncoding transcripts

TL Romanuik, T Ueda, N Le, S Haile, TMK Yong… - The American journal of …, 2009 - Elsevier
Levels of 27 transcripts were investigated as potential novel markers for prostate cancer,
including genes encoding plasma membrane proteins (ADAM2, ELOVL5, MARCKSL1 …

[HTML][HTML] Molecular pathology of prostate cancer: a practical approach

T Vlajnic, L Bubendorf - Pathology, 2021 - Elsevier
While localised prostate cancer can be cured by local treatment,'high-risk'prostate cancer
often progresses to castration resistant disease and remains incurable with a dismal …