Objectives WHO guidelines on ART define the HIV-1 viral load (VL) threshold for treatment
failure at 1000 copies/mL. The Switch Either near Suppression Or THOusand (SESOTHO) …

Objectives Limited availability of viral load (VL) monitoring in HIV treatment programmes in
sub-Saharan Africa can delay switching to second-line ART, leading to the accumulation of …

Objectives To determine the impact of pretreatment low-abundance HIV-1 drug-resistant
variants (LA-DRVs) on virological failure (VF) among HIV-1/TB-co-infected individuals …

Abstract Background The World Health Organization (WHO) recommends viral load (VL)
measurement as the preferred monitoring strategy for HIV-infected individuals on …

Background Current World Health Organization (WHO) antiretroviral therapy (ART)
guidelines define virologic failure as two consecutive viral load (VL) measurements≥ 1,000 …

Abstract Background In sub-Saharan Africa, detecting resistance-associated mutations
(RAMs) at failure of first-line ART with two NRTIs plus an NNRTI predicts improved …

Background Although there are a number of studies comparing the currently recommended
preferred and alternative first-line (1L) antiretroviral therapy (ART) regimens on clinical …

Objectives To assess whether a single instance of low-level viraemia (LLV) is associated
with the presence of drug resistance mutations (DRMs) and predicts subsequent virological …

Background. After the scale-up of antiretroviral therapy (ART) for human immunodeficiency
virus (HIV) infection in Africa, increasing numbers of patients have pretreatment drug …

Objectives Emerging resistance to antiretroviral drugs may jeopardize the achievements of
improved access to ART. We compared the prevalence of different resistance mutations in …