The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

Tissue-resident phagocytes are responsible for the routine binding, engulfment, and
resolution of their meals. Such populations of cells express appropriate surface receptors …

Mammalian photoreceptor outer segment renewal is a highly coordinated process that
hinges on timed cell signaling between photoreceptor neurons and the adjacent retinal …

Lipids constitute a significant group of biological metabolites and the building blocks of all
cell membranes. The abundance and stoichiometries of different lipid species are known to …

The retinal pigment epithelium (RPE) is a simple epithelium interposed between the neural
retina and the choroid. Although only 1 cell-layer in thickness, the RPE is a virtual …

Accumulation of indigestible lipofuscin and decreased mitochondrial energy production are
characteristic age-related changes of post-mitotic retinal pigment epithelial (RPE) cells in the …

The retinal pigment epithelium (RPE) is a particularly vulnerable tissue to age-dependent
degeneration. Over the lifespan, the RPE develops an expanded endo-lysosomal …

Background The retina is a light-sensitive tissue lining the inner surface of the eye and one
of the few human organs whose cholesterol maintenance is still poorly understood …

The retinal pigment epithelium (RPE) is a single layer of post-mitotic cells, which functions
both as a selective barrier to and a vegetative regulator of the overlying photoreceptor layer …