Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

Epigenetic, along with genetic mechanisms, is essential for natural evolution and
maintenance of specific patterns of gene expression in mammalians. Global epigenetic …

Epigenetic mechanisms control gene expression during normal development and their
aberrant regulation may lead to human diseases including cancer. Natural phytochemicals …

The term epigenetics is defined as heritable changes in gene expression patterns that occur
without changes in DNA sequence. Epigenetic changes according to this definition are …

In addition to genetic events, a variety of epigenetic events have been widely reported to
contribute to the onset of many diseases including cancer. DNA methylation and histone …

In addition to the genetic alterations, observed in cancer cells, are mitotically heritable
changes in gene expression not encoded by the DNA sequences, which are referred to as …

Epigenetic modifications are heritable yet reversible, essential for normal physiological
functions and biological development. Aberrant epigenetic modifications, including DNA …

Epigenetics refers to heritable changes in gene expression and chromatin structure without
change in a DNA sequence. Several epigenetic modifications and respective regulators …

The hallmarks of carcinogenesis are characterized by alterations in the expression of
multiple genes that occur via genetic and epigenetic alterations, leading to genome …

Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …