[HTML][HTML] The role of epigenetic modifications in human cancers and the use of natural compounds as epidrugs: Mechanistic pathways and pharmacodynamic actions

A Bouyahya, H Mechchate, L Oumeslakht, I Zeouk… - Biomolecules, 2022 - mdpi.com
Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

[HTML][HTML] Epigenetic mechanisms as a new approach in cancer treatment: An updated review

M Fardi, S Solali, MF Hagh - Genes & diseases, 2018 - Elsevier
Epigenetic, along with genetic mechanisms, is essential for natural evolution and
maintenance of specific patterns of gene expression in mammalians. Global epigenetic …

[HTML][HTML] Dietary compounds as epigenetic modulating agents in cancer

Á Carlos-Reyes, JS López-González… - Frontiers in …, 2019 - frontiersin.org
Epigenetic mechanisms control gene expression during normal development and their
aberrant regulation may lead to human diseases including cancer. Natural phytochemicals …

[HTML][HTML] Targeting epigenetic mechanisms: potential of natural products in cancer chemoprevention

AT Hauser, M Jung - Planta medica, 2008 - thieme-connect.com
The term epigenetics is defined as heritable changes in gene expression patterns that occur
without changes in DNA sequence. Epigenetic changes according to this definition are …

Epi-drugs to fight cancer: from chemistry to cancer treatment, the road ahead

A Mai, L Altucci - The international journal of biochemistry & cell biology, 2009 - Elsevier
In addition to genetic events, a variety of epigenetic events have been widely reported to
contribute to the onset of many diseases including cancer. DNA methylation and histone …

Epigenetics and cancer treatment

LS Kristensen, HM Nielsen, LL Hansen - European journal of …, 2009 - Elsevier
In addition to the genetic alterations, observed in cancer cells, are mitotically heritable
changes in gene expression not encoded by the DNA sequences, which are referred to as …

Progress and promises of epigenetic drugs and epigenetic diets in cancer prevention and therapy: A clinical update

P Mondal, J Natesh, D Penta, SM Meeran - Seminars in Cancer Biology, 2022 - Elsevier
Epigenetic modifications are heritable yet reversible, essential for normal physiological
functions and biological development. Aberrant epigenetic modifications, including DNA …

[HTML][HTML] Natural products impacting DNA methyltransferases and histone deacetylases

SH Akone, F Ntie-Kang, F Stuhldreier… - Frontiers in …, 2020 - frontiersin.org
Epigenetics refers to heritable changes in gene expression and chromatin structure without
change in a DNA sequence. Several epigenetic modifications and respective regulators …

Natural compounds: role in reversal of epigenetic changes

R Aggarwal, M Jha, A Shrivastava, AK Jha - Biochemistry (moscow), 2015 - Springer
The hallmarks of carcinogenesis are characterized by alterations in the expression of
multiple genes that occur via genetic and epigenetic alterations, leading to genome …

Current paradigms in epigenetic anticancer therapeutics and future challenges

M Singh, V Kumar, N Sehrawat, M Yadav… - Seminars in Cancer …, 2022 - Elsevier
Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …