Susceptibility of immature and adult brains to seizure effects

SR Haut, J Veliškova, SL Moshé - The Lancet Neurology, 2004 - thelancet.com
The extent that status epilepticus (SE), but also brief seizures, affects neuronal structure and
function has been the subject of much clinical and experimental research. There is a …

Acute and chronic effects of seizures in the developing brain: lessons from clinical experience

EM Mizrahi - Epilepsia, 1999 - Wiley Online Library
Seizures in the neonate are often considered a form of status epilepticus (SE) because they
are relatively prolonged, difficult to control with antiepileptic drugs (AEDs), and may be …

Effects of seizures on developmental processes in the immature brain

Y Ben-Ari, GL Holmes - The Lancet Neurology, 2006 - thelancet.com
Infants and children are at a high risk for seizures compared with adults. Although most
seizures in children are benign and result in no long-term consequences, increasing …

Do seizures affect the developing brain? Lessons from the laboratory

R Sankar, JM Rho - Journal of child neurology, 2007 - journals.sagepub.com
Laboratory models of prolonged seizures and status epilepticus in developing animals
demonstrate age-and model-dependent propensity for brain injury. Even in models without …

Effects of neonatal seizures on subsequent seizure-induced brain injury

R Schmid, P Tandon, CE Stafstrom, GL Holmes - Neurology, 1999 - AAN Enterprises
Background: Although seizures are very common in neonates and are often the harbinger of
poor neurologic outcome, there is controversy regarding the degree of brain damage …

[引用][C] Recurrent seizures in the developing brain are harmful

CG Wasterlain - Epilepsia, 1997 - Wiley Online Library
Pediatricians like children. In their desire to help their beloved patients and to reassure
anxious families, they are sometimes reluctant to consider the possibility that their traditional …

Do seizures cause brain damage?

GL Holmes - Epilepsia, 1991 - europepmc.org
Children with epilepsy are at significant risk for cognitive impairment and behavioral
abnormalities. In most children with epilepsy, the likely reason for cognitive impairment is the …

Seizure-induced damage in the developing human: relevance of experimental models

GL Holmes, R Khazipov, Y Ben-Ari - Progress in Brain Research, 2002 - Elsevier
A considerable amount of money and effort is spent every year investigating the effects of
seizure on the developing rodent brain. A critical question is the relevance of these studies …

Long‐term effects of status epilepticus in the immature brain are specific for age and model

MR Cilio, Y Sogawa, BH Cha, X Liu, LT Huang… - …, 2003 - Wiley Online Library
Purpose: Status epilepticus (SE) is more common in children than adults and has a high
mortality and morbidity rate. SE in adult rats results in long‐term disturbances in learning …

Seizure-induced neuronal injury: animal data

GL Holmes - Neurology, 2002 - AAN Enterprises
One of the oldest questions in epilepsy is whether seizures are a cause or a result of brain
damage. Animal data have provided us with insights into the relationship between seizures …