Susceptibility of immature and adult brains to seizure effects
The extent that status epilepticus (SE), but also brief seizures, affects neuronal structure and
function has been the subject of much clinical and experimental research. There is a …
function has been the subject of much clinical and experimental research. There is a …
Acute and chronic effects of seizures in the developing brain: lessons from clinical experience
EM Mizrahi - Epilepsia, 1999 - Wiley Online Library
Seizures in the neonate are often considered a form of status epilepticus (SE) because they
are relatively prolonged, difficult to control with antiepileptic drugs (AEDs), and may be …
are relatively prolonged, difficult to control with antiepileptic drugs (AEDs), and may be …
Effects of seizures on developmental processes in the immature brain
Y Ben-Ari, GL Holmes - The Lancet Neurology, 2006 - thelancet.com
Infants and children are at a high risk for seizures compared with adults. Although most
seizures in children are benign and result in no long-term consequences, increasing …
seizures in children are benign and result in no long-term consequences, increasing …
Do seizures affect the developing brain? Lessons from the laboratory
Laboratory models of prolonged seizures and status epilepticus in developing animals
demonstrate age-and model-dependent propensity for brain injury. Even in models without …
demonstrate age-and model-dependent propensity for brain injury. Even in models without …
Effects of neonatal seizures on subsequent seizure-induced brain injury
R Schmid, P Tandon, CE Stafstrom, GL Holmes - Neurology, 1999 - AAN Enterprises
Background: Although seizures are very common in neonates and are often the harbinger of
poor neurologic outcome, there is controversy regarding the degree of brain damage …
poor neurologic outcome, there is controversy regarding the degree of brain damage …
[引用][C] Recurrent seizures in the developing brain are harmful
CG Wasterlain - Epilepsia, 1997 - Wiley Online Library
Pediatricians like children. In their desire to help their beloved patients and to reassure
anxious families, they are sometimes reluctant to consider the possibility that their traditional …
anxious families, they are sometimes reluctant to consider the possibility that their traditional …
Do seizures cause brain damage?
GL Holmes - Epilepsia, 1991 - europepmc.org
Children with epilepsy are at significant risk for cognitive impairment and behavioral
abnormalities. In most children with epilepsy, the likely reason for cognitive impairment is the …
abnormalities. In most children with epilepsy, the likely reason for cognitive impairment is the …
Seizure-induced damage in the developing human: relevance of experimental models
GL Holmes, R Khazipov, Y Ben-Ari - Progress in Brain Research, 2002 - Elsevier
A considerable amount of money and effort is spent every year investigating the effects of
seizure on the developing rodent brain. A critical question is the relevance of these studies …
seizure on the developing rodent brain. A critical question is the relevance of these studies …
Long‐term effects of status epilepticus in the immature brain are specific for age and model
MR Cilio, Y Sogawa, BH Cha, X Liu, LT Huang… - …, 2003 - Wiley Online Library
Purpose: Status epilepticus (SE) is more common in children than adults and has a high
mortality and morbidity rate. SE in adult rats results in long‐term disturbances in learning …
mortality and morbidity rate. SE in adult rats results in long‐term disturbances in learning …
Seizure-induced neuronal injury: animal data
GL Holmes - Neurology, 2002 - AAN Enterprises
One of the oldest questions in epilepsy is whether seizures are a cause or a result of brain
damage. Animal data have provided us with insights into the relationship between seizures …
damage. Animal data have provided us with insights into the relationship between seizures …