Astrocytes in chronic pain and itch
Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence
suggests that a number of neurological and neuropsychiatric disorders, including chronic …
suggests that a number of neurological and neuropsychiatric disorders, including chronic …
Astrocytes in chronic pain: cellular and molecular mechanisms
HJ Lu, YJ Gao - Neuroscience Bulletin, 2023 - Springer
Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-
effects of therapies. Astrocytes are the most abundant glial cells in the central nervous …
effects of therapies. Astrocytes are the most abundant glial cells in the central nervous …
Mode of action of astrocytes in pain: From the spinal cord to the brain
Y Chen, X Feng, CW Cheung, JA Liu - Progress in Neurobiology, 2022 - Elsevier
Chronic pain is a maladaptive condition affecting 7%− 10% of the population worldwide and
can be accompanied by depression, anxiety, and insomnia. In particular, chronic pain is …
can be accompanied by depression, anxiety, and insomnia. In particular, chronic pain is …
Role of astrocytes in pain
CY Chiang, BJ Sessle, JO Dostrovsky - Neurochemical research, 2012 - Springer
Over the last decade, a series of studies has demonstrated that glia in the central nervous
system play roles in many aspects of neuronal functioning including pain processing …
system play roles in many aspects of neuronal functioning including pain processing …
Pathological and protective roles of glia in chronic pain
ED Milligan, LR Watkins - Nature reviews neuroscience, 2009 - nature.com
Glia have emerged as key contributors to pathological and chronic pain mechanisms. On
activation, both astrocytes and microglia respond to and release a number of signalling …
activation, both astrocytes and microglia respond to and release a number of signalling …
An update on reactive astrocytes in chronic pain
T Li, X Chen, C Zhang, Y Zhang, W Yao - Journal of neuroinflammation, 2019 - Springer
Chronic pain is a critical clinical problem with an increasing prevalence. However, there are
limited effective prevention measures and treatments for chronic pain. Astrocytes are the …
limited effective prevention measures and treatments for chronic pain. Astrocytes are the …
[HTML][HTML] Central nervous system targets: glial cell mechanisms in chronic pain
CR Donnelly, AS Andriessen, G Chen, K Wang… - …, 2020 - Elsevier
Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …
Modulation of pain and itch by spinal glia
M Tsuda - Neuroscience bulletin, 2018 - Springer
Chronic pain and itch are a pathological operation of the somatosensory system at the levels
of primary sensory neurons, spinal cord and brain. Pain and itch are clearly distinct …
of primary sensory neurons, spinal cord and brain. Pain and itch are clearly distinct …
[HTML][HTML] Spinal astrocytes in pain processing: non-neuronal cells as therapeutic targets
CI Svensson, E Brodin - Molecular interventions, 2010 - triggered.edina.clockss.org
The treatment of chronic inflammatory and neuropathic pain is a major concern, and the
need for new more effective analgesics with less adverse effects is immense. Traditionally …
need for new more effective analgesics with less adverse effects is immense. Traditionally …
Glia and pain: is chronic pain a gliopathy?
Activation of glial cells and neuro–glial interactions are emerging as key mechanisms
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …