BACKGROUND AND PURPOSE Sirtuin 6 (SIRT6) is involved in regulation of glucose and
fat metabolism. However, its possible contribution to cardiac dysfunction remains to be …

SIRT6 is a member of the sirtuin family of class III histone deacetylases. It plays important
roles in regulating genomic stability, metabolism, stress response and aging. Our previous …

The activation of signal transducer and activator of transcription 3 (STAT3) is critical for the
development of cardiac hypertrophy and heart failure. Sirtuin 6 (SIRT6) protects …

Abstract Sirtuin 6 (SIRT6) is an important modulator of cardiovascular functions in health and
diseases. However, the exact role of SIRT6 in heart disease is poorly defined. We …

Calorie restriction is considered to be the best environmental intervention providing health
benefits to mammals. The underlying mechanism of this intervention seems to be controlled …

Hypertension is the key factor for the development of cardiac fibrosis and diastolic
dysfunction. Our previous study showed that knockout of sirtuin 3 (SIRT3) resulted in …

Abstract Sirtuin 3 (SIRT3) is a deacetylase that modulates proteins that control metabolism
and protects against oxidative stress. Modulation of SIRT3 activity has been proposed as a …

Background Impairment of glycolytic metabolism is suggested to contribute to diabetic
cardiomyopathy. In this study, we explored the roles of SIRT3 (Sirtuin 3) on cardiomyocyte …

Differentiation of cardiac fibroblasts (CFs) into myofibroblasts represents a key event in
cardiac fibrosis that contributes to pathologic cardiac remodeling. However, regulation of this …

Background Emerging evidence indicates that impaired angiogenesis may contribute to
hypertension‐induced cardiac remodeling. The nicotinamide adenine dinucleotide …