Cell‐surface central nervous system autoantibodies: clinical relevance and emerging paradigms

SR Irani, JM Gelfand, A Al‐Diwani… - Annals of …, 2014 - Wiley Online Library
The recent discovery of several potentially pathogenic autoantibodies has helped identify
patients with clinically distinctive central nervous system diseases that appear to benefit from …

Clinical and experimental studies of potentially pathogenic brain-directed autoantibodies: current knowledge and future directions

J Varley, A Vincent, SR Irani - Journal of neurology, 2015 - Springer
The field of neuronal surface-directed antibody-mediated diseases of the central nervous
system has dramatically expanded in the last few years and now forms an important cluster …

[HTML][HTML] Autoantibody-mediated diseases of the CNS: structure, dysfunction and therapy

J Varley, J Taylor, SR Irani - Neuropharmacology, 2018 - Elsevier
The field of neuronal autoantibody associated diseases of the central nervous system has
expanded dramatically in the last few years. The range of identified neuronal and glial …

Antibody-mediated autoimmune diseases of the CNS: challenges and approaches to diagnosis and management

E Sechi, EP Flanagan - Frontiers in neurology, 2021 - frontiersin.org
Antibody-mediated disorders of the central nervous system (CNS) are increasingly
recognized as neurologic disorders that can be severe and even life-threatening but with the …

The autoantibody-mediated encephalitides: from clinical observations to molecular pathogenesis

S Ramanathan, A Al-Diwani, P Waters, SR Irani - Journal of Neurology, 2021 - Springer
The autoimmune encephalitis (AE) syndromes have been characterised by the detection of
autoantibodies in serum and/or cerebrospinal fluid which target the extracellular domains of …

Do neuronal autoantibodies cause psychosis? A neuroimmunological perspective

E Coutinho, P Harrison, A Vincent - Biological psychiatry, 2014 - Elsevier
In the last decade, autoantibodies targeting proteins on the neuronal surface and that are
believed to be directly pathogenic have been described in patients with autoimmune …

[HTML][HTML] Autoimmune encephalitis—new awareness, challenging questions

SR Irani, A Vincent - Discovery medicine, 2011 - discoverymedicine.com
The field of autoimmune encephalopathies has expanded rapidly in the last few years. It is
now well-established that a substantial proportion of encephalitides are associated with …

Anti-neuronal autoantibodies: current diagnostic challenges

C Probst, S Saschenbrecker, W Stoecker… - Multiple sclerosis and …, 2014 - Elsevier
The spectrum of neurological autoimmune diseases has expanded substantially in the last
15 years due to the discovery of new anti-neuronal antibodies. There are at present …

Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system

N Sinmaz, T Nguyen, F Tea, RC Dale… - Journal of …, 2016 - Springer
Background Our knowledge of autoantibody-associated diseases of the central (CNS) and
peripheral (PNS) nervous systems has expanded greatly over the recent years. A number of …

Detection methods for autoantibodies in suspected autoimmune encephalitis

G Ricken, C Schwaiger, D De Simoni, V Pichler… - Frontiers in …, 2018 - frontiersin.org
This review provides an overview on different antibody test methods that can be applied in
cases of suspected paraneoplastic neurological syndromes (PNS) and anti-neuronal …