Unraveling the Interplay of Dopamine, Carbon Monoxide, and Heme Oxygenase in Neuromodulation and Cognition
The dopaminergic system plays important roles in neuromodulation, including prominent
roles in complex neurological functions such as cognition, reward, motivation, and memory …
roles in complex neurological functions such as cognition, reward, motivation, and memory …
Carbon monoxide and the brain: time to rethink the dogma
KA Hanafy, J Oh, LE Otterbein - Current pharmaceutical …, 2013 - ingentaconnect.com
Carbon Monoxide (CO), long thought to be a simple environmental pollutant is now known
to have a critical role in cellular functions ranging from vasodilation to circadian rhythms. In …
to have a critical role in cellular functions ranging from vasodilation to circadian rhythms. In …
Carbon monoxide actuates O2-limited heme degradation in the rat brain
FJ Cronje, MS Carraway, JJ Freiberger… - Free Radical Biology …, 2004 - Elsevier
The biochemical paradigm for carbon monoxide (CO) is driven by the century-old Warburg
hypothesis: CO alters O2-dependent functions by binding heme proteins in competitive …
hypothesis: CO alters O2-dependent functions by binding heme proteins in competitive …
Carbon monoxide and the CNS: challenges and achievements
CSF Queiroga, A Vercelli… - British Journal of …, 2015 - Wiley Online Library
Haem oxygenase (HO) and its product carbon monoxide (CO) are associated with
cytoprotection and maintenance of homeostasis in several different organs and tissues. This …
cytoprotection and maintenance of homeostasis in several different organs and tissues. This …
Mitochondria are the source of hydrogen peroxide for dynamic brain-cell signaling
Hydrogen peroxide (H2O2) is emerging as a ubiquitous small-molecule messenger in
biology, particularly in the brain, but underlying mechanisms of peroxide signaling remain …
biology, particularly in the brain, but underlying mechanisms of peroxide signaling remain …
Carbon monoxide: from poison to clinical trials
R Siracusa, A Schaufler, V Calabrese, PM Fuller… - Trends in …, 2021 - cell.com
Every cell has a highly sophisticated system for regulating heme levels, which is particularly
important with regard to turnover. Heme degradation generates CO and while CO has long …
important with regard to turnover. Heme degradation generates CO and while CO has long …
Interaction of carbon monoxide with transition metals: evolutionary insights into drug target discovery
R Foresti, R Motterlini - Current drug targets, 2010 - ingentaconnect.com
The perception that carbon monoxide (CO) is poisonous and life-threatening for mammalian
organisms stems from its intrinsic propensity to bind iron in hemoglobin, a reaction that …
organisms stems from its intrinsic propensity to bind iron in hemoglobin, a reaction that …
RETRACTED ARTICLE: The quantum physiology of oxygen; from electrons to the evolution of redox signaling in the human brain
DM Bailey - Bioelectronic Medicine, 2018 - Springer
Rising atmospheric oxygen (O 2) levels provided a selective pressure for the evolution of O
2-dependent micro-organisms that began with the autotrophic eukaryotes. Since these …
2-dependent micro-organisms that began with the autotrophic eukaryotes. Since these …
Oxygen, evolution and redox signalling in the human brain; quantum in the quotidian
DM Bailey - The Journal of physiology, 2019 - Wiley Online Library
Rising atmospheric oxygen (O2) levels provided a selective pressure for the evolution of O2‐
dependent micro‐organisms that began with the autotrophic eukaryotes. Since these …
dependent micro‐organisms that began with the autotrophic eukaryotes. Since these …
Role of carbon monxide in cardiovascular function
W Durante, FK Johnson… - Journal of cellular and …, 2006 - Wiley Online Library
Carbon monoxide (CO) is an endogenously derived gas formed from the breakdown of
heme by the enzyme heme oxygenase. Although long considered an insignificant and …
heme by the enzyme heme oxygenase. Although long considered an insignificant and …
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