To assess the potential of intrinsically disordered proteins (IDPs) as drug design targets, we
have analyzed the ligand‐binding cavities of two datasets of IDPs (containing 37 and 16 …

Intrinsically disordered proteins (IDPs) exist in highly dynamic conformational ensembles,
which pose a major obstacle for drug development targeting IDPs because traditional …

Various studies have revealed that important biological functions of many proteins do not
require stable well‐defined structure in solution, with many functions originating from the …

Introduction: There is a natural abundance of intrinsically disordered proteins or intrinsically
disordered protein regions (IDPs or IDPRs), that is, biologically active proteins/regions …

Intrinsically disordered proteins (IDPs) were found to be widely associated with human
diseases and may serve as potential drug design targets. However, drug design targeting …

Although under physiological conditions, intrinsically disordered proteins (IDPs) fail to form a
definite 3D structure and instead exist as ensembles of conformations, they perform critical …

The past decade has witnessed great advances in our understanding of protein structure‐
function relationships in terms of the ubiquitous existence of intrinsically disordered proteins …

Intrinsically disordered proteins (IDPs) are proteins that perform important biological
functions without well‐defined structures under physiological conditions. IDPs can form …

Intrinsically disordered proteins (IDPs) are unorthodox proteins that do not form three-
dimensional structures under non-denaturing conditions, but perform important biological …

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …