Environmental adaptation and diversification of bacterial two-component systems

AF Alvarez, D Georgellis - Current Opinion in Microbiology, 2023 - Elsevier
Bacterial two-component systems (TCS) are versatile signaling mechanisms that govern
cellular responses to diverse environmental cues. These systems rely on phosphoryl-group …

An atlas of bacterial two-component systems reveals function and plasticity in signal transduction

Y Xie, J Li, Y Ding, X Shao, Y Sun, F Xie, S Liu, S Tang… - Cell reports, 2022 - cell.com
Two-component systems (TCSs) consist of the biggest group of signal transduction
pathways in biology. Although TCSs play key roles in sensing signals to sustain survival and …

Tools to map target genes of bacterial two‐component system response regulators

L Rajeev, ME Garber… - Environmental …, 2020 - Wiley Online Library
Studies on bacterial physiology are incomplete without knowledge of the signalling and
regulatory systems that a bacterium uses to sense and respond to its environment. Two …

Unique patterns and biogeochemical relevance of two-component sensing in marine bacteria

NA Held, MR McIlvin, DM Moran, MT Laub, MA Saito - MSystems, 2019 - Am Soc Microbiol
Two-component sensory (TCS) systems link microbial physiology to the environment and
thus may play key roles in biogeochemical cycles. In this study, we surveyed the TCS …

Leveraging the histidine kinase-phosphatase duality to sculpt two-component signaling

SSM Meier, E Multamäki, AT Ranzani, H Takala… - Nature …, 2024 - nature.com
Bacteria must constantly probe their environment for rapid adaptation, a crucial need most
frequently served by two-component systems (TCS). As one component, sensor histidine …

Elucidation of regulatory modes for five two-component systems in Escherichia coli reveals novel relationships

KS Choudhary, JA Kleinmanns, K Decker, AV Sastry… - Msystems, 2020 - Am Soc Microbiol
Escherichia coli uses two-component systems (TCSs) to respond to environmental signals.
TCSs affect gene expression and are parts of E. coli's global transcriptional regulatory …

Bacterial adaptation of respiration from oxic to microoxic and anoxic conditions: redox control

E Bueno, S Mesa, EJ Bedmar… - Antioxidants & redox …, 2012 - liebertpub.com
Under a shortage of oxygen, bacterial growth can be faced mainly by two ATP-generating
mechanisms:(i) by synthesis of specific high-affinity terminal oxidases that allow bacteria to …

Cross-talk and specificity in two-component signal transduction pathways

R Agrawal, BK Sahoo, DK Saini - Future microbiology, 2016 - Taylor & Francis
Two-component signaling systems (TCSs) are composed of two proteins, sensor kinases
and response regulators, which can cross-talk and integrate information between them by …

Signal transduction and adaptive regulation through bacterial two-component systems: the Escherichia coli AtoSC paradigm

DA Kyriakidis, E Tiligada - Amino Acids, 2009 - Springer
Adaptive signal transduction within microbial cells involves a multi-faceted regulated
phosphotransfer mechanism that comprises structural rearrangements of sensor histidine …

The regulatory hierarchy following signal integration by the CbrAB two-component system: diversity of responses and functions

E Monteagudo-Cascales, E Santero, I Canosa - Genes, 2022 - mdpi.com
CbrAB is a two-component system, unique to bacteria of the family Pseudomonaceae,
capable of integrating signals and involved in a multitude of physiological processes that …