Exosome camouflaged coordination-assembled Iridium (III) photosensitizers for apoptosis-autophagy-ferroptosis induced combination therapy against melanoma

T Feng, Z Tang, J Karges, J Shen, C Jin, Y Chen, Y Pan… - Biomaterials, 2023 - Elsevier
Melanoma represents the most fatal form of skin cancer due to its resistance mechanisms
and high capacity for the development of metastases. Among other medicinal techniques …

A Biodegradable Iridium (III) Coordination Polymer for Enhanced Two‐Photon Photodynamic Therapy Using an Apoptosis–Ferroptosis Hybrid Pathway

L Ke, F Wei, L Xie, J Karges, Y Chen… - Angewandte Chemie …, 2022 - Wiley Online Library
The clinical application of photodynamic therapy is hindered by the high glutathione
concentration, poor cancer‐targeting properties, poor drug loading into delivery systems …

Ferroptosis-apoptosis combined anti-melanoma immunotherapy with a NIR-responsive upconverting mSiO2 photodynamic platform

D Li, J Ren, J Li, Y Zhang, Y Lou, J Zhu, P Liu… - Chemical Engineering …, 2021 - Elsevier
Photodynamic therapy (PDT) is an appealing treatment for oncologic skin diseases owing to
its high spatiotemporally selectivity and non-invasive features. However, its application in …

Highly Efficient Far‐Red/NIR‐Absorbing Neutral Ir (III) Complex Micelles for Potent Photodynamic/Photothermal Therapy

B Liu, J Jiao, W Xu, M Zhang, P Cui, Z Guo… - Advanced …, 2021 - Wiley Online Library
A critical issue in photodynamic therapy (PDT) is inadequate reactive oxygen species (ROS)
generation in tumors, causing inevitable survival of tumor cells that usually results in tumor …

Folate-targeted iridium complexes amplify photodynamic therapy efficacy through ferroptosis

X He, L Wei, J Chen, S Ge… - Inorganic Chemistry …, 2023 - pubs.rsc.org
Interest in targeted cancer therapies with fewer side effects has increased in recent years.
Photodynamic therapy (PDT) involves the use of photosensitizers (PSs) and light to …

Iridium (III) complex–derived polymeric micelles with low dark toxicity and strong NIR excitation for phototherapy and chemotherapy

J Zhao, X Zhang, L Fang, C Gao, C Xu, S Gou - Small, 2020 - Wiley Online Library
Iridium (III) complexes are potent candidates for photodynamic therapy. However, their
clinical usage is impeded by their poor water solubility, high dark toxicity, and negligible …

Rosmarinic acid‐crosslinked supramolecular nanoassembly with self‐regulated photodynamic and anti‐metastasis properties for synergistic photoimmunotherapy

Y Zhou, Y Zhang, C Jiang, Y Chen, F Tong, X Yang… - Small, 2023 - Wiley Online Library
A primary concern about photodynamic therapy (PDT) is its inability to regulate the
generation levels of reactive oxidative species (ROS) based on the complex …

[HTML][HTML] A mitochondria-localized iridium (iii) photosensitizer for two-photon photodynamic immunotherapy against melanoma

L Wang, J Karges, F Wei, L Xie, Z Chen, G Gasser… - Chemical …, 2023 - pubs.rsc.org
Conventional photodynamic therapy mainly causes a therapeutic effect on the primary tumor
through the localized generation of reactive oxygen species, while metastatic tumors remain …

Redox-activated porphyrin-based liposome remote-loaded with indoleamine 2, 3-dioxygenase (IDO) inhibitor for synergistic photoimmunotherapy through induction of …

D Liu, B Chen, Y Mo, Z Wang, T Qi, Q Zhang… - Nano …, 2019 - ACS Publications
Immunotherapy through stimulating the host immune system has emerged as a powerful
therapeutic strategy for various malignant and metastatic tumors in the clinic. However …

Rational assembly of a biointerfaced core@ shell nanocomplex towards selective and highly efficient synergistic photothermal/photodynamic therapy

C Qin, J Fei, A Wang, Y Yang, J Li - Nanoscale, 2015 - pubs.rsc.org
To optimize synergistic cancer therapy, we rationally assemble an inorganic–organic
nanocomplex using a folate-modified lipid bilayer spread on photosensitizer-entrapped …