Application of a simple and rapid LC-MS/MS method for determination of danshensu in human plasma for an oral pharmacokinetic study of Danshen granules in …

S Fu, L Li, F Qiu, B Wang, W Du, L Feng - Analytical Methods, 2014 - pubs.rsc.org
A simple and rapid liquid chromatography-electrospray ionization-tandem mass
spectrometry method is developed and validated for the determination of danshensu in …

Determination of danshensu in urine and its pharmacokinetics in human

Q Liu, RB Chao - Yao xue xue bao= Acta Pharmaceutica Sinica, 2003 - europepmc.org
To determine Danshensu in urine and study its pharmacokinetics in human. A solid phase
extraction-HPLC method was used for determination of Danshensu in urine of human. HPLC …

Determination and pharmacokinetics of danshensu in rat plasma after oral administration of danshen extract using liquid chromatography/tandem mass spectrometry

W Li, ZW Li, JP Han, XX Li, J Gao, CX Liu - European journal of drug …, 2008 - Springer
A liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed
and validated for the determination and pharmacokinetics of danshensu in rat plasma …

Qualitative and quantitative analysis of Compound Danshen Dripping Pills by CS-HPLC

X Zhao, Z Zhu, A Liu, Z Wang… - Chinese Traditional …, 1992 - wprim.whocc.org.cn
AIM: To establish a method using HPLC with column switching for determination of
Danshensu in human blood serums. RESULTS: A linearity range of 0.0248~ 0.3720? g was …

MEKC determination of pharmacokinetic and tissue distribution study of Danshensu in rabbits

Y YANG, R YANG, Y WEI - Chinese Journal of …, 2008 - ingentaconnect.com
A MEKC method was used to determine Danshensu in New Zealand white rabbit blood
plasma and tissuesliverlungkidneybrainheart and spleenand to study its pharmacokinetics …

New metabolite profiles of Danshensu in rats by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry

J Gu, L Feng, M Zhang, D Qin, J Jiang, X Cheng… - … of Chromatography B, 2014 - Elsevier
In our research, ultraperformance liquid chromatography/quadrupole-time-of-flight mass
spectrometry (U-HPLC/Q-TOF-MS) was established for analyzing the metabolite profiles of …

Identification of metabolites of Danshensu in vivo in rats

XD Mei, YQ Wang, ZJ Wang, WJ Zhao… - Zhongguo Zhong yao …, 2018 - europepmc.org
To identify the metabolites of Danshensu in plasma and urine in rats by using UHPLC-LTQ-
Orbitrap method. After oral gavage of Danshensu CMC-Na suspension in SD rats, urine and …

Simultaneous determination and pharmacokinetic study of water‐soluble and lipid‐soluble components of danshen in rat plasma using HPLC‐UV method

X Wang, ZR Zhang, H Fu, J Liu, Q Chen… - Biomedical …, 2007 - Wiley Online Library
A sensitive and specific HPLC‐UV method was developed for the simultaneous
determination of major active components of danshen in rat plasma. Both water‐soluble and …

Determination of danshensu in rat plasma and tissues by high-performance liquid chromatography

Z Zhang, M Xu, S Sun, H Guo, X Qiao… - Journal of …, 2008 - academic.oup.com
A systematic study on pharmacokinetcs and tissue distribution of danshensu (one of the
major active components from Salvia miltiorrhiza) is conducted using a rapid and sensitive …

Identification of a major metabolite of danshensu in rat urine and simultaneous determination of danshensu and its metabolite in plasma: Application to a …

X Wang, W Li, X Ma, K Yan, Y Chu… - Drug Testing and …, 2015 - Wiley Online Library
Danshensu, as the effective component of Salvia miltiorrhiza (Danshen), has been widely
used in clinical studies for treatment of cardiovascular diseases in China. A new metabolite …