Conspectus Cellular senescence can be defined as an irreversible stopping of cell
proliferation that arises in response to various stress signals. Cellular senescence is …

Organismal ageing is a complex process driving progressive impairment of functionality and
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …

Over a half-century ago, Dr. Leonard Hayflick described the phenotype of a finite lifespan for
human fibroblasts being passaged in in vitro cell culture (Hayflick et al., 1961), a …

Cellular senescence is defined as irreversible cell cycle arrest caused by various processes
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …

Senescence is a state of permanent cell cycle arrest. Cellular senescence can promote
tissue remodelling but can negatively affect regenerative capacities of tissues and contribute …

Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Senescence is a cellular stress response that involves prolonged cell survival, a quasi-
irreversible proliferative arrest and a modification of the transcriptome that sometimes …

Cellular senescence, a stable cell division arrest caused by severe damage and stress, is a
hallmark of aging in vertebrates including humans. With progressing age, senescent cells …

Cellular senescence is characterized by the permanent arrest of cell proliferation and is a
response to endogenous and exogenous stress. The continuous accumulation of senescent …

Senescence is a cell state that contributes to several homeostatic and pathologic processes.
In addition to being induced in somatic cells in response to replicative exhaustion …