Plasticity of cancer invasion and metastasis depends on the ability of cancer cells to switch
between collective and single-cell dissemination, controlled by cadherin-mediated cell–cell …

In this article, we explore a non-canonical form of collective cell migration, displayed by the
metastatic murine mammary carcinoma cell line 4T1. We show here that in sparsely plated …

Cancer invasion programs are adaptive by switching between metastatic collective and
single-cell dissemination; however, current intravital microscopy models for epithelial cancer …

Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show
that CAFs exert a physical force on cancer cells that enables their collective invasion. Force …

Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-
extracellular matrix interactions. For instance, normal epithelial cells maintain tissue …

Metastasis is the major driver of death in patients with cancer. Invasion of surrounding
tissues and metastasis have been proposed to initiate following loss of the intercellular …

Background Alterations in the cadherin-catenin adhesion complexes are involved in tumor
initiation, progression and metastasis. However, the functional implication of distinct …

Highlights•Cancer invasion is accomplished through interactions among distinct cell
types.•Both epithelial–epithelial and epithelial–stromal interactions regulate …

Copyright 1996 Scientific American, Inc. tulate their “area code” hypothesis, that a cell has
on its surface an address system—written in one set of molecules and readable by …

Epithelial tissues are essential for barrier function, secretion, and regulation of fluid
transport. Their function requires cell polarity and cell–cell adhesion, mediated through …