Biomarkers-guided precision therapeutics has revolutionized the clinical development and
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …

Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell
death and survival, playing a pivotal role in multiple interconnected cell signaling …

Abstract PI3K/AKT signalling is commonly disrupted in human cancers, with AKT being a
central component of the pathway, influencing multiple processes that are directly involved …

Akt (protein kinase B) is a serine/threonine kinase which is a central regulator of widely
divergent cellular processes including proliferation, differentiation, migration, survival and …

Introduction: Targeted therapies in cancer aim to inhibit specific molecular targets
responsible for enhanced tumor growth. AKT/PKB (protein kinase B) is a serine threonine …

Growth factor signaling plays a pivotal role in diverse biological functions, such as cell
growth, apoptosis, senescence, and migration and its deregulation has been linked to …

The serine/threonine kinase Akt functions intracellularly as a cardinal nodal point for a
constellation of converging upstream signaling pathways, which involve stimulation of …

Importance of the field: The evolution of targeted therapies is dependent upon identification
of cellular moieties that can be pharmacologically modulated. As one such example, the …

The serine/threonine kinase Akt/PKB pathway presents an exciting new target for molecular
therapeutics, as it functions as a cardinal nodal point for transducing extracellular (growth …

More than a decade after their discovery, the three AKT kinase family members have
emerged as central players in the signaling cascades that regulate cell growth, proliferation …