Introduction: Successful healing of large bone defects (LBDs) is a complicated phenomenon
because the body's natural ability often fails to effectively repair the LBDs. New modalities …

The increased concentration of platelets within platelet-rich plasma (PRP) provides a vehicle
to deliver supra-physiologic concentrations of growth factors to an injury site, possibly …

Bone has the ability to completely regenerate under normal healing conditions. Although
fractures generally heal uneventfully, healing problems such as delayed union or nonunion …

Background: Recently, there is an increasing interest in the therapeutic potential of platelet-
rich plasma (PRP) for bone fracture treatment. Nevertheless, the effect of PRP for bone …

Background Treatment of large bone defects and fracture healing complications (delayed
and non-union) presents a substantial challenge for orthopaedic surgeons. Given that bone …

Purpose The treatment of large bone defects represents a significant challenge for
orthopaedic surgeons. In recent years, biologic agents have also been used to further …

Human bone is a tissue with a fairly remarkable inherent capacity for regeneration; however,
this regenerative capacity has its limitations, and defects larger than a critical size lack the …

The use of platelet-rich plasma (PRP) in bone reconstruction therapy was introduced in the
late 1990s. Since then, many scientists and clinicians have employed it in orthopaedic and …

Platelet-rich plasma (PRP) is an autologous platelet concentrate prepared from the whole
blood that is activated to release growth factors (GFs) and cytokines and has been shown to …

Although mechanical stabilisation has been a hallmark of orthopaedic surgical
management, orthobiologics are now playing an increasing role. Platelet-rich plasma (PRP) …