Electron deficient, bivalent sulfur atoms have two areas of positive electrostatic potential, a
consequence of the low-lying σ* orbitals of the C–S bond that are available for interaction …

Thiols can engage favorably with aromatic rings in S–H/π interactions, within abiological
systems and within proteins. However, the underlying bases for S–H/π interactions are not …

In organic molecules a divalent sulfur atom sometimes adopts weak coordination to a
proximate heteroatom (X). Such hypervalent nonbonded S··· X interactions can control the …

Weak nonbonded interactions between a divalent sulfur (S) atom and a main-chain carbonyl
oxygen (O) atom have recently been characterized in proteins. However, they have shown …

Sulfur is an ubiquitous heteroatom in medicinal chemistry [1]. Its prevalence is often credited
to its ability to exist in many oxidation states, whilst also being capable of bonding to a …

Introduction Sulfur-containing functional groups are privileged motifs that occur in various
pharmacologically effective substances and several natural products. Various functionalities …

Abstract When a Group V, VI, or VII atom forms a covalent bond, its bonding orbital has a
deficiency of electronic charge in its outer (noninvolved) lobe. This is called a σ‐hole. If the …

The importance of Sulfur centred hydrogen bonds (SCHBs) cannot be underestimated given
the current day knowledge of its non-covalent interactions prevalent in many biopolymers as …

In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

The interaction between aromatic rings and sulfur atoms in the side chains of amino acids is
a factor in the formation and stabilization of α-helices in proteins. We studied the H2S …