Congenic mouse strains provide a unique resource for genetic dissection and biological
characterization of chromosomal regions associated with diabetes progression in the …

Twenty diabetes susceptibility loci on 12 mouse chromosomes have been identified to
control the development of type 1 diabetes at the level of either initiation of insulitis or …

The nonobese diabetic (NOD) mouse is genetically predisposed for the spontaneous
development of type 1 diabetes. Linkage analyses have identified at least 19 susceptibility …

The nonobese diabetic (NOD) mouse recapitulates many aspects of the pathogenesis of
type 1 diabetes in humans, including inheritance as a complex trait. More than 20 Idd loci …

Type 1 diabetes is a multigenic autoimmune disease, the genetic basis for which is perhaps
best characterized in the nonobese diabetic (NOD) mouse model. We previously located a …

Twenty-four named Idd loci that contribute to the development of autoimmune diabetes in
the nonobese diabetic (NOD) mouse have been mapped by linkage and congenic analysis …

Type 1 diabetes in the nonobese diabetic (NOD) mouse is a multifactorial and polygenic
disease. The NOD-derived genetic factors that contribute to type 1 diabetes are named Idd …

The NOD mouse has been a critical tool in the quest to understand the genetic control of
type 1 diabetes (T1D), and over 25 murine insulin-dependent diabetes (Idd) loci that …

Although once widely anticipated to unlock how human type 1 diabetes (T1D) develops,
extensive study of the nonobese diabetic (NOD) mouse has failed to yield effective …

Nonobese diabetic (NOD) mice congenic for C57BL/10 (B10)-derived genes in the Idd9
region of chromosome 4 are highly protected from type 1 diabetes (T1D). Idd9 has been …