Tyrosine kinases (TKs) are involved in key signaling events/pathways that regulate cancer
cell proliferation, apoptosis, angiogenesis and metastasis. Deregulated activity of TKs has …

Tyrosine kinases (TKs) play an important role in pathways that regulate cancer cell
proliferation, apoptosis, angiogenesis and metastasis. Aberrant activity of TKs has been …

The phenomenon of multidrug resistance (MDR) has attenuated the efficacy of anticancer
drugs and the possibility of successful cancer chemotherapy. ATP-binding cassette (ABC) …

The past decade has seen tremendous efforts in the research and development of new
chemotherapeutic drugs using target-based approaches. These efforts have led to the …

Recently, a large number of tyrosine kinase inhibitors (TKIs) have been developed as
anticancer agents. These TKIs can specifically and selectively inhibit tumor cell growth and …

Tyrosine kinase inhibitors (TKIs) are a new class of highly-selective and molecularly
targeted anticancer agents. Most of these newly developed TKIs are hydrophobic, thus …

Introduction: Anticancer tyrosine kinase inhibitors (TKIs) are small molecule hydrophobic
compounds designed to arrest aberrant signaling pathways in malignant cells. Multidrug …

Resistance to conventional and target specific antitumor drugs still remains one of the major
cause of treatment failure and patience death. This condition often involves ATP-binding …

Recent antitumor drug research has seen the development of a large variety of tyrosine
kinase inhibitors (TKIs) with increasing specificity and selectivity. These are highly promising …

Tyrosine kinase inhibitors (TKIs) are being increasingly used to treat various malignancies.
Although they were designed to target aberrant tyrosine kinases, they are also intimately …