From evolutionary genetics to human immunology: how selection shapes host defence genes
LB Barreiro, L Quintana-Murci - Nature Reviews Genetics, 2010 - nature.com
Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …
selective pressure on the human genome. Data from population genetic studies, including …
Evolutionary insights into host–pathogen interactions from mammalian sequence data
Infections are one of the major selective pressures acting on humans, and host-pathogen
interactions contribute to shaping the genetic diversity of both organisms. Evolutionary …
interactions contribute to shaping the genetic diversity of both organisms. Evolutionary …
Human genome variability, natural selection and infectious diseases
M Fumagalli, M Sironi - Current opinion in immunology, 2014 - Elsevier
Highlights•Demographic history and natural selection shaped human genome
diversity.•Infections represented a major environmental selective pressure for human …
diversity.•Infections represented a major environmental selective pressure for human …
Human immunology through the lens of evolutionary genetics
L Quintana-Murci - Cell, 2019 - cell.com
Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …
Detecting such selection signatures in ancient and modern human genomes can thus help …
Population genetic tools for dissecting innate immunity in humans
L Quintana-Murci, AG Clark - Nature Reviews Immunology, 2013 - nature.com
Innate immunity involves direct interactions between the host and microorganisms, both
pathogenic and symbiotic, so natural selection is expected to strongly influence genes …
pathogenic and symbiotic, so natural selection is expected to strongly influence genes …
Balancing selection is the main force shaping the evolution of innate immunity genes
The evolutionarily recent geographic expansion of humans, and the even more recent
development of large, relatively dense human settlements, has exposed our species to new …
development of large, relatively dense human settlements, has exposed our species to new …
Natural selection and infectious disease in human populations
EK Karlsson, DP Kwiatkowski, PC Sabeti - Nature Reviews Genetics, 2014 - nature.com
The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …
genetic variation in modern populations, and this has important implications for the growing …
[HTML][HTML] Genetic ancestry and natural selection drive population differences in immune responses to pathogens
Individuals from different populations vary considerably in their susceptibility to immune-
related diseases. To understand how genetic variation and natural selection contribute to …
related diseases. To understand how genetic variation and natural selection contribute to …
Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases
The field of human genetics of infectious diseases defines the genes and alleles rendering
individuals (clinical genetics) and populations (epidemiological genetics) vulnerable to …
individuals (clinical genetics) and populations (epidemiological genetics) vulnerable to …
Human genetic susceptibility to infectious disease
SJ Chapman, AVS Hill - Nature Reviews Genetics, 2012 - nature.com
Recent genome-wide studies have reported novel associations between common
polymorphisms and susceptibility to many major infectious diseases in humans. In parallel …
polymorphisms and susceptibility to many major infectious diseases in humans. In parallel …