Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …

Infections are one of the major selective pressures acting on humans, and host-pathogen
interactions contribute to shaping the genetic diversity of both organisms. Evolutionary …

Highlights•Demographic history and natural selection shaped human genome
diversity.•Infections represented a major environmental selective pressure for human …

Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …

Innate immunity involves direct interactions between the host and microorganisms, both
pathogenic and symbiotic, so natural selection is expected to strongly influence genes …

The evolutionarily recent geographic expansion of humans, and the even more recent
development of large, relatively dense human settlements, has exposed our species to new …

The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …

Individuals from different populations vary considerably in their susceptibility to immune-
related diseases. To understand how genetic variation and natural selection contribute to …

The field of human genetics of infectious diseases defines the genes and alleles rendering
individuals (clinical genetics) and populations (epidemiological genetics) vulnerable to …

Recent genome-wide studies have reported novel associations between common
polymorphisms and susceptibility to many major infectious diseases in humans. In parallel …