High-throughput RNAi screenings (HTS) allow quantifying the impact of the deletion of each
gene in any particular function, from virus-host interactions to cell differentiation. However …

Background The analysis of high-throughput screening data sets is an expanding field in
bioinformatics. High-throughput screens by RNAi generate large primary data sets which …

Background Big data is becoming ubiquitous in biology, and poses significant challenges in
data analysis and interpretation. RNAi screening has become a workhorse of functional …

Over the last decade, cell-based RNAi screens have emerged as a powerful research tool.
High-content RNAi screening in particular has been successfully used to systematically …

RNA interference (RNAi) is an effective tool for genome-scale, high-throughput analysis of
gene function. In the past five years, a number of genome-scale RNAi high-throughput …

RNA interference (RNAi) screening is a powerful technology for functional characterization
of biological pathways. Interpretation of RNAi screens requires computational and statistical …

Background A systems biology interpretation of genome-scale RNA interference (RNAi)
experiments is complicated by scope, experimental variability and network signaling …

Background RNAi screening is a powerful method to study the genetics of intracellular
processes in metazoans. Technically, the approach has been largely inspired by techniques …

RNA interference and morphological profiling—the measurement of thousands of
phenotypes from individual cells by microscopy and image analysis—are a potentially …

RNA interference-based screening is a powerful new genomic technology that addresses
gene function en masse. To evaluate factors influencing hit list composition and …