The pericyte of the pancreatic islet regulates capillary diameter and local blood flow
Efficient insulin secretion requires a well-functioning pancreatic islet microvasculature. The
dense network of islet capillaries includes the islet pericyte, a cell that has barely been …
dense network of islet capillaries includes the islet pericyte, a cell that has barely been …
The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action
OC Richards, SM Raines, AD Attie - Endocrine reviews, 2010 - academic.oup.com
The pathogenesis of type 2 diabetes is intimately intertwined with the vasculature. Insulin
must efficiently enter the bloodstream from pancreatic β-cells, circulate throughout the body …
must efficiently enter the bloodstream from pancreatic β-cells, circulate throughout the body …
Islet pericytes are required for β-cell maturity
A Sasson, E Rachi, L Sakhneny, D Baer… - Diabetes, 2016 - Am Diabetes Assoc
β-Cells rely on the islet microenvironment for their functionality and mass. Pericytes, along
with endothelial cells, make up the dense islet capillary network. However, although the role …
with endothelial cells, make up the dense islet capillary network. However, although the role …
The role of vascular cells in pancreatic beta-cell function
G Burganova, C Bridges, P Thorn… - Frontiers in …, 2021 - frontiersin.org
Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …
Integrated pancreatic blood flow: bidirectional microcirculation between endocrine and exocrine pancreas
MP Dybala, A Kuznetsov, M Motobu… - Diabetes, 2020 - Am Diabetes Assoc
The pancreatic islet is a highly vascularized endocrine micro-organ. The unique architecture
of rodent islets, a so-called core-mantle arrangement seen in two-dimensional images, led …
of rodent islets, a so-called core-mantle arrangement seen in two-dimensional images, led …
Pancreatic islet vasculature adapts to insulin resistance through dilation and not angiogenesis
Pancreatic islets adapt to insulin resistance through a complex set of changes, including β-
cell hyperplasia and hypertrophy. To determine if islet vascularization changes in response …
cell hyperplasia and hypertrophy. To determine if islet vascularization changes in response …
From endothelial to β cells: insights into pancreatic islet microendothelium
The microvasculature is a key interface between blood and tissues and participates in
numerous pathophysiological processes. The heterogeneity of microvascular endothelial …
numerous pathophysiological processes. The heterogeneity of microvascular endothelial …
The vascular order of islet cellular perfusion in the human pancreas
JI Stagner, E Samols - Diabetes, 1992 - Am Diabetes Assoc
The vascular order of pancreatic islet cellular perfusion is important in the intraislet
regulation of hormone secretion. Establishment of the sequence of interaction is …
regulation of hormone secretion. Establishment of the sequence of interaction is …
Microcirculation of the islets of Langerhans: Long Beach Veterans Administration Regional Medical Education Center Symposium
FC Brunicardi, J Stagner, S Bonner-Weir, H Wayland… - Diabetes, 1996 - go.gale.com
To discuss the controversy of the current concept of islet microcirculation, an international
symposium was held at the Long Beach Veterans Administration Regional Medical …
symposium was held at the Long Beach Veterans Administration Regional Medical …
Microvascular development: learning from pancreatic islets
I Konstantinova, E Lammert - Bioessays, 2004 - Wiley Online Library
Microvascular development is determined by the interplay between tissue cells and
microvascular endothelial cells. Because the pancreatic islet is an organ composed mainly …
microvascular endothelial cells. Because the pancreatic islet is an organ composed mainly …
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