Efficient insulin secretion requires a well-functioning pancreatic islet microvasculature. The
dense network of islet capillaries includes the islet pericyte, a cell that has barely been …

The pathogenesis of type 2 diabetes is intimately intertwined with the vasculature. Insulin
must efficiently enter the bloodstream from pancreatic β-cells, circulate throughout the body …

β-Cells rely on the islet microenvironment for their functionality and mass. Pericytes, along
with endothelial cells, make up the dense islet capillary network. However, although the role …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

The pancreatic islet is a highly vascularized endocrine micro-organ. The unique architecture
of rodent islets, a so-called core-mantle arrangement seen in two-dimensional images, led …

Pancreatic islets adapt to insulin resistance through a complex set of changes, including β-
cell hyperplasia and hypertrophy. To determine if islet vascularization changes in response …

The microvasculature is a key interface between blood and tissues and participates in
numerous pathophysiological processes. The heterogeneity of microvascular endothelial …

The vascular order of pancreatic islet cellular perfusion is important in the intraislet
regulation of hormone secretion. Establishment of the sequence of interaction is …

To discuss the controversy of the current concept of islet microcirculation, an international
symposium was held at the Long Beach Veterans Administration Regional Medical …

Microvascular development is determined by the interplay between tissue cells and
microvascular endothelial cells. Because the pancreatic islet is an organ composed mainly …