Cytochrome P450 (CYP450) enzymes are the most important metabolizing enzyme family
exists among all organs. Apart from their role in the deactivation of most endogenous …

Importance of the field: Among various human CYPs, CYP2E1 is of particular interest
because of its involvement in the metabolic activation of many low molecular mass …

Cytochromes P450s (CYPs) constitute a superfamily of enzymes that catalyze the
metabolism of drugs and other substances. Endogenous substrates of CYPs include …

CYP1A1 and CYP1B1 are extrahepatic P450 family members involved in the metabolism of
procarcinogens, such as PAHs, heterocyclic amines and halogen-containing organic …

Background Drug-metabolizing enzymes play a role in chemical carcinogenesis through
enzymatic activation of procarcinogens to biologically reactive metabolites. The role of gene …

Abstract Background Single nucleotide polymorphisms (SNPs) in several CYP genes have
been associated with altered breast cancer (BC) risk in different populations. Despite this …

Human cytochrome P450 (CYP) enzymes play a key role in the metabolism of drugs and
environmental chemicals. Several CYP enzymes metabolically activate procarcinogens to …

Abstract Cytochrome P450 1B1 (CYP1B1) participates in the metabolic activation of a
number of procarcinogens including benzo [a] pyrene and the hydroxylation of 17β-estradiol …

Abstract CYP450 3A4 (CYP3A4), encoded by the CYP3A4 gene, is a major enzyme
catalyzing the metabolism of both endogenous and exogenous agents that may play a role …

The cytochromes P450 (CYPs) are key enzymes in cancer formation and cancer treatment.
They mediate the metabolic activation of numerous precarcinogens and participate in the …