Role of metabolic enzymes P450 (CYP) on activating procarcinogen and their polymorphisms on the risk of cancers
X He, S Feng - Current drug metabolism, 2015 - ingentaconnect.com
Cytochrome P450 (CYP450) enzymes are the most important metabolizing enzyme family
exists among all organs. Apart from their role in the deactivation of most endogenous …
exists among all organs. Apart from their role in the deactivation of most endogenous …
CYP2E1 and risk of chemically mediated cancers
DT Trafalis, ES Panteli, A Grivas, C Tsigris… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: Among various human CYPs, CYP2E1 is of particular interest
because of its involvement in the metabolic activation of many low molecular mass …
because of its involvement in the metabolic activation of many low molecular mass …
[HTML][HTML] Cytochrome P450: polymorphisms and roles in cancer, diabetes and atherosclerosis
Cytochromes P450s (CYPs) constitute a superfamily of enzymes that catalyze the
metabolism of drugs and other substances. Endogenous substrates of CYPs include …
metabolism of drugs and other substances. Endogenous substrates of CYPs include …
The activation of procarcinogens by CYP1A1/1B1 and related chemo-preventive agents: a review
Y Li, J Cui, J Jia - Current Cancer Drug Targets, 2021 - ingentaconnect.com
CYP1A1 and CYP1B1 are extrahepatic P450 family members involved in the metabolism of
procarcinogens, such as PAHs, heterocyclic amines and halogen-containing organic …
procarcinogens, such as PAHs, heterocyclic amines and halogen-containing organic …
Genetic variability in CYP3A4 and CYP3A5in primary liver, gastric and colorectal cancer patients
G Gervasini, E García-Martín, JM Ladero, R Pizarro… - BMC cancer, 2007 - Springer
Background Drug-metabolizing enzymes play a role in chemical carcinogenesis through
enzymatic activation of procarcinogens to biologically reactive metabolites. The role of gene …
enzymatic activation of procarcinogens to biologically reactive metabolites. The role of gene …
Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population
LN Al-Eitan, DM Rababa'h, MA Alghamdi… - BMC medical …, 2019 - Springer
Abstract Background Single nucleotide polymorphisms (SNPs) in several CYP genes have
been associated with altered breast cancer (BC) risk in different populations. Despite this …
been associated with altered breast cancer (BC) risk in different populations. Despite this …
Cytochrome P450 gene polymorphism and cancer
JAG Agúndez - Current drug metabolism, 2004 - ingentaconnect.com
Human cytochrome P450 (CYP) enzymes play a key role in the metabolism of drugs and
environmental chemicals. Several CYP enzymes metabolically activate procarcinogens to …
environmental chemicals. Several CYP enzymes metabolically activate procarcinogens to …
Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer
J Watanabe, T Shimada, EMJ Gillam… - Pharmacogenetics …, 2000 - journals.lww.com
Abstract Cytochrome P450 1B1 (CYP1B1) participates in the metabolic activation of a
number of procarcinogens including benzo [a] pyrene and the hydroxylation of 17β-estradiol …
number of procarcinogens including benzo [a] pyrene and the hydroxylation of 17β-estradiol …
CYP3A4* 1B polymorphism and cancer risk: a HuGE review and meta-analysis
LP Zhou, F Yao, H Luan, YL Wang, XH Dong… - Tumor Biology, 2013 - Springer
Abstract CYP450 3A4 (CYP3A4), encoded by the CYP3A4 gene, is a major enzyme
catalyzing the metabolism of both endogenous and exogenous agents that may play a role …
catalyzing the metabolism of both endogenous and exogenous agents that may play a role …
Cytochrome P450 pharmacogenetics and cancer
C Rodriguez-Antona, M Ingelman-Sundberg - Oncogene, 2006 - nature.com
The cytochromes P450 (CYPs) are key enzymes in cancer formation and cancer treatment.
They mediate the metabolic activation of numerous precarcinogens and participate in the …
They mediate the metabolic activation of numerous precarcinogens and participate in the …