Continuous subcutaneous use of levetiracetam: a retrospective review of tolerability and clinical effects

C Rémi, S Lorenzl, B Vyhnalek, K Rastorfer… - Journal of Pain & …, 2014 - Taylor & Francis
To evaluate the tolerability and clinical effects of subcutaneous (SC) levetiracetam for the
treatment of epileptic seizures in a palliative care setting, we conducted a retrospective chart …

Subcutaneous levetiracetam for the management of seizures at the end of life: an audit and updated literature review

A Sutherland, C Meldon, T Harrison… - Journal of Palliative …, 2021 - liebertpub.com
Objectives: The aim of this study is to report the results of a second cycle audit of the use of
subcutaneous levetiracetam (Keppra®) and an updated literature review of management of …

Pharmacokinetics of subcutaneous levetiracetam in palliative care patients

P Papa, F Oricchio, M Ginés, C Maldonado… - Journal of Palliative …, 2021 - liebertpub.com
Background: Seizure control is challenging in the palliative care setting. Subcutaneous (SC)
levetiracetam (LEV) is currently an off-label route of administration and effectiveness …

Subcutaneous levetiracetam for the management of seizures at the end of life

AE Sutherland, J Curtin, V Bradley, O Bush… - BMJ Supportive & …, 2018 - spcare.bmj.com
Objectives To report the results of a combined case series analysis of subcutaneous
levetiracetam (Keppra) for the management of seizures in palliative care patients. Methods A …

Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam …

S Ramael, F De Smedt, N Toublanc, C Otoul… - Clinical …, 2006 - Elsevier
Background: Antiepileptic drugs are usually administere dorally, but alternative routes of
drug delivery may be required when oral administration is not feasible. Objective: The …

Levetiracetam intravenous infusion: a randomized, placebo‐controlled safety and pharmacokinetic study

S Ramael, A Daoust, C Otoul, N Toublanc… - …, 2006 - Wiley Online Library
Purpose: The primary objective of this placebo‐controlled study was to evaluate the safety
and tolerability of levetiracetam (LEV) administered intravenously (IV) at higher doses and/or …

Continuous subcutaneous levetiracetam in the management of seizures at the end of life: a case report

GH Wells, LD Mason, E Foreman… - Age and Ageing, 2016 - academic.oup.com
We report the case of a man who developed seizures on a background of recurrent
metastatic squamous cell carcinoma with intracranial involvement. Initial seizure control with …

Levetiracetam: a long‐term follow‐up study of efficacy and safety

J Bauer, E Ben‐Menachem, G Krämer… - Acta neurologica …, 2006 - Wiley Online Library
Objectives–To evaluate the efficacy and safety of long‐term add‐on treatment with
levetiracetam 1,000–4,000 mg/day. Patients and methods–In this multicenter, open‐label …

Pharmacokinetics, safety and bioequivalence of levetiracetam intravenous infusion and oral tablets in healthy Chinese subjects

N Toublanc, X Du, Y Liu, Q Chen, P Singh… - Clinical drug …, 2015 - Springer
Abstract Background and Objective Levetiracetam is available in China as adjunctive oral
therapy for partial-onset seizures. This study was conducted to evaluate the bioequivalence …

Levetiracetam: relative bioavailability and bioequivalence of a 10% oral solution (750 mg) and 750‐mg tablets

R Coupez, R Straetemans, G Sehgal… - The Journal of …, 2003 - Wiley Online Library
Levetiracetam, an antiepileptic drug, is used worldwide as an adjunctive treatment for partial‐
onset seizures. The availability of a new oral solution formulation would provide an …